Molecule Information

General Information of the Molecule (ID: Mol02224)

• Name: Long non-protein coding RNA (LOC284930) ,Homo sapiens
• Synonyms: LOC284930
• Molecule Type: LncRNA
• Gene Name: LOC284930

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Neurotoxicity [1]

• Resistant Disease: Neurotoxicity [ICD-11: NE61.0]
• Resistant Drug: Hydrogen peroxide
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SH-SY5Y cells; Abdomen; Homo sapiens (Human); CVCL_0019
• Experiment for Molecule Alteration: Overexpression assay; Knockdown assay
• Experiment for Drug Resistance: CCK8 assay; LDH assay; Caspase-3 activity assay
• Mechanism Description: Lnc-EPIC1 downregulation mediates H2O2-induced neuronal cell death.

References

• Ref 1: LncRNA EPIC1 downregulation mediates hydrogen peroxide-induced neuronal cell injuryAging (Albany NY). 2019 Dec 8;11(23):11463-11473. doi: 10.18632/aging.102545. Epub 2019 Dec 8.