Disease Information

General Information of the Disease (ID: DIS00186)

• Name: Pediculosis
• ICD: ICD-11: 1G00

Type(s) of Resistant Mechanism of This Disease

  DISM: Drug Inactivation by Structure Modification

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Ivermectin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Key Molecule: Cytochrome P450 family 1 subfamily A member 1 (CYP1A1) [1]

• Resistant Disease: Pediculosis [ICD-11: 1G00.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Ivermectin
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Pediculus humanus; 121225
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Disk diffusion assay
• Mechanism Description: Phylogenetic relatedness of P450 and ABC transporter genes over-transcribed following ivermectin exposure.Knockdown of CYP9AG2 P450 and ABCC4 transporter gene expression by RNA interference and subsequent increase in the sensitivity of lice to ivermectin.

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: ATP-binding cassette sub-family C4 (ABCC4) [1]

• Resistant Disease: Pediculosis [ICD-11: 1G00.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Ivermectin
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Pediculus humanus; 121225
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Disk diffusion assay
• Mechanism Description: Phylogenetic relatedness of P450 and ABC transporter genes over-transcribed following ivermectin exposure.Knockdown of CYP9AG2 P450 and ABCC4 transporter gene expression by RNA interference and subsequent increase in the sensitivity of lice to ivermectin.

References

• Ref 1: Ivermectin: From theory to clinical application .Int J Antimicrob Agents. 2019 Aug;54(2):134-142. doi: 10.1016/j.ijantimicag.2019.05.003. Epub 2019 May 7. 10.1016/j.ijantimicag.2019.05.003