Disease Information
General Information of the Disease (ID: DIS00124)
Name |
Seasonal allergic rhinitis
|
---|---|
ICD |
ICD-11: CA08
|
Type(s) of Resistant Mechanism of This Disease
IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Fexofenadine
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Irregularity in Drug Uptake and Drug Efflux (IDUE) | ||||
Key Molecule: ATP-binding cassette sub-family B5 (ABCB5) | [1] | |||
Sensitive Disease | Seasonal allergic rhinitis [ICD-11: CA08.0] | |||
Molecule Alteration | Expression | Down-regulation |
||
Sensitive Drug | Fexofenadine | |||
Experimental Note | Identified from the Human Clinical Data | |||
Experiment for Molecule Alteration |
qPCR | |||
Experiment for Drug Resistance |
Ussing chamber system assay | |||
Mechanism Description | Digoxin and fexofenadine (each 5 uM) were selected as P-gp substrates, and sulfasalazine and rosuvastatin (each 5 uM) were selected as BCRP substrates to evaluate the efflux transport mediated by P-gp and BCRP. PSC833 (15 uM) and ko143 (15 uM) were used as typical inhibitors of P-gp and BCRP, respectively. Serosal-to-mucosal transport of all the tested P-gp and BCRP substrate drugs was significantly decreased or tended to decrease in the presence of P-gp/BCRP inhibitor cocktail. |
References
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