Disease Information

General Information of the Disease (ID: DIS00026)

• Name: Nocardiosis
• ICD: ICD-11: 1C1B

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Rifampin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: DNA-directed RNA polymerase subunit beta 2 (RPOB2) [1]

• Resistant Disease: Nocardiosis [ICD-11: 1C1B.0]
• Molecule Alteration: Expression; Inherence
• Resistant Drug: Rifampin
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Nocardia farcinica IFM 10152; 247156
• Experiment for Molecule Alteration: PCR; Southern analysis
• Experiment for Drug Resistance: Brain heart infusion (BHI) broth assay
• Mechanism Description: RpoB2 may have reduced binding affinity for RIF due to amino acid substitutions and is capable of functioning in the presence of RIF instead of RpoB. Besides, RNAP with RpoB2 may elicit expression of a latent RIF resistance gene which may be present in the genome.

References

• Ref 1: Contribution of rpoB2 RNA polymerase beta subunit gene to rifampin resistance in Nocardia species. Antimicrob Agents Chemother. 2006 Apr;50(4):1342-6. doi: 10.1128/AAC.50.4.1342-1346.2006.