Molecule Information

General Information of the Molecule (ID: Mol05984)

Name	DPP10-AS1 ,Homo sapiens
Molecule Type	Long non-coding RNA
Sequence	AGCTCCGCCACTGCGCGCGCTCCAGCGCCCCAGAAGGCAGGGGGCAGCCCGGGGACCGGG GTCCCGGAGCCCCGTGGGAGGCGGGCAACACCTGTCGGGACCCGAGGGCGTGTCTGAGAT TGTGGCCTGAGGTGCTGCGCCTTCCGATCCGGGGCAGCGGGCGTCCTGTAGCTGCGCCTT CCGAATCCAGCCCAGATTCTCCTACCAGCTGCTTGGGTCACGTCGGTGGAACTCCTAAAG GGATGCCTTCAAAATGTGTGAATAAGCTTCAATCAGACTGCCCTTCCCAAAGAAAATAAC TATAAATGCTGGAAAAACTACAAAACAGCCACCTGAAGGCACTGGCGAGAGACAAAAGCA AGCAAATTCTGGAGAAGAGTCAACACTTGGAAGAAGGGAGCTGCACTGGGTACATGGGGA AGGAACAGTGTCTCTGCATGAGAATGGCCAAAGAACAAGATACATTTCCCCGTGGAGAGC AATCCTAGAGAGAGGGAAGCATGGGTCAGAATAAGGTGTACTGGCCCCAGGGTAATAGCA TGTATTTCTGTTGCATTGGTGTTTCCAAAATAATGCTTCGGTTCCAAGTTTCAGGAATTG GTTGGGGGAGCATGGGGATCATACAGTGATTCAGGAGCTTCCTTGCAAGTAAGTGAGTGA GCCAATCAAATAATTTATGTTTAAATCTTTCACTGTGTTAAATGTTGAAAAATAAAGCAA GTGAATTCCAAAAAAAAAAAAAAA Click to Show/Hide
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Enzalutamide

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Prostate cancer [ICD-11: 2C82.0]				[1]
Resistant Disease	Prostate cancer [ICD-11: 2C82.0]			Disease Info
Resistant Drug	Enzalutamide			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	LNCaP cells	Prostate	Homo sapiens (Human)	CVCL_0395
	C4-2B cells	Prostate	Homo sapiens (Human)	CVCL_4784
Experiment for Molecule Alteration	Western blot
Experiment for Drug Resistance	MTT assay
Mechanism Description	This gene is up-regulated in enzalutamide-resistance cells

References

Ref 1	Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab ResistanceMol Cancer Ther. 2018 Feb;17(2):521-531. doi: 10.1158/1535-7163.MCT-17-0575. Epub 2017 Nov 20.