Molecule Information

General Information of the Molecule (ID: Mol05977)

Name	LINC00467 ,Homo sapiens
Molecule Type	Long non-coding RNA
Sequence	GTGGCGTAGGCCGGACATTTCTAGTCGACTGTTGCGCGTGCGCGCGCTGTGACGTTCCCT ACGCGGTCGGGCGTTGGGTTTCGCGGCGCTCGCCGCACTGGTTGTTCAGCACCTTCGGTC CGGTTGAGGTTGTCAAGTCGGACCAAACAGGTTGTTTCTCTGCAGTTTCCAACATGGCAG GGAGGTTTAATAGACATGGATAAGAAGTCCACTCACAGAAATCCTGAAGATGCCAGGGCT GGCAAATATGAAGGTAAACACAAACGAAAGAAAAGAAGAAAGCAAAACCAAAACCAGCAC CGATCCCGACATAGATCAGTGACGTCTTTTTCTTCAGATGATCCTATGTTTCCTTCTTCC TCATCATCGTCTTCAGGAAGCCAGACAGATTCAAGTATTGAAGATGCTGCCAAGGGAAAA ATTAAGAAGAAGAGAAGAGAGAAAACAAATAAATGGGAAAAAAGAAAGGACAAAATATGA AACACCAAGAAAAAGAGAAGGAAAAAAAGGAGGAAACAACCACATATGTCACCTTTCCAA GAGGGACTGAAACTGGGCTGACCCTTTTGATTTCCAAGCTCAGCGTTTTGGTGTAAGGCG GCCAAAGAAGGATGCGGAGCCCAGCACTGTGAAGCCTACAAAAACATTGATGCGCTGGCT TGGGGATTTGAATTTGAACATCTTTCACACTAAGTTCAGACTCATGAAACCAATCTTCAG ATGCTCTGTAAACCACATAATAAAGAGTTTGGAAATTAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAA Click to Show/Hide
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Oxaliplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Colorectal cancer [ICD-11: 2B91.1]				[1]
Resistant Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Resistant Drug	Oxaliplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HCT116 cells	Colon	Homo sapiens (Human)	CVCL_0291
	HCT-8 cells	Colon	Homo sapiens (Human)	CVCL_2478
Experiment for Molecule Alteration	qPCR
Mechanism Description	We constructed a ceRNA network containing 503 lncRNA-miRNA-mRNA regulatory pairs, 210 lncRNA-miRNA pairs, 382 miRNA-mRNA pairs, and 212 mRNA co-expression pairs. The differentially expressed lncRNA, miRNA and mRNA were verified by qPCR. One lncRNA (HOTAIR) and 14 mRNAs significantly correlated with patient prognosis.

References

Ref 1	Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):133-6. doi: 10.4103/0971-5851.158852.