Molecule Information

General Information of the Molecule (ID: Mol05931)
Name
LINC00520 ,Homo sapiens
Molecule Type
Long non-coding RNA
Sequence
CATGTAAGATATGACTGTGCTCCTCCTTCACCTTCTGCCATGATTGTGAGGCCTCCACAG
CCATGTGGAACTCCATGAGTATGACTATGTGCTGAGTCCTGTGAGTCCTCCTACTGAATC
ATCAAAGCCAGGGGGGAAGCTGTTTTTCCCTCTTTGGGGTCTCAGAGAGATTGGTGGCAA
GGACTCCTGGGAAGAGAAAAGCTGAAGGACACTCTGGCAAGAGGTACCACCTCTCACTGG
CTGCCCAAGCAAGATTCTATGGCTTGGAATAATTCTCAGCGACTCACTCATCAAAGGGCA
TCTATCTAGAAGCCCTGCTCCTTCAGGGACATCTGAGGTTGATGAGCTGATCCAATAAGC
CATCAGAGCTGGAATAGTAGTAGTTAACAATGGCTCTCTGCACTCTTTTTAAATAACTTT
GCTTTTCAGGCCAAGGTGAGAGCCTCGTGGGAATTTCACAAATTTTATAGAAGCAGAGGA
GTGCTATTTGAGCAAGGGGCGGATAACACCTACAATCCACTCAGGATTTCCAAGCATAGC
CGGATGCAGAAGTACTCATACTTCACTACAGAATCACCTGGGGAGCTTTTAACCTTCTGA
TTCTAGTGTTTCCCTCTGGCAGATGGAGACAGAAACTTGACTGGGCTCAGGAATATGTGT
TTTTAAAATTCTCCAGAAGATTTTAATGCAGTACAAGTAAGAAGACAGGACTGCAATTCA
CAAGAACAGTATATCCTGGTGATTCCTCAGAACAGAACAGACTCAAAAAAAAAAAAAAAA
GAAGAAGACAAAAACAAAGATAACATGAAACCAGATTCCACAACCATGTTTCAAGTGACC
TATGTGAGTCAGGCCCATGAGACACATACTACACCAGTTTCAGTGAAGCCTCACAAAATT
TAGGGGGGTAGAGGAAAGGGTCCTATGCCCATTTCATAGATGAACAAACTAAGGACTTAA
TAGATTTCAACAATTTGTTCAAAGTCTCTACCTTAAAGGATTTTGGGGTTCTGGTTTTTG
TTTTTACCTGCCCTGGTAACTCTTCTAAGAATGAGCCAAGAAGAAGACAACCTTCTAAGA
TACTTTTCCTGCCCTCCAAGGGCTGTGGAGAATCTGATAGGGTTGGAGCTGCCCTCTCCT
CTTCCCAGAGACACTGCCCCACAATCCCATCAAGTCTGACTGGTACCAACGACTCCAGGG
GGCCTCTGCCTTCAGAACTGTATAGGCCTGTGTGGGCACCAGTCTTTACATCCATGTTCC
CTCTCCCTCGAGGACCCAGGTTGACCTGTCCAAGAGCTCTCTCATCATGCTGAATTTTGG
TGACAGCATAGGGTGAGCCTGTGGATTCTACAGCTCAGCAAACCTCCAGCCAAGTAGTTT
CCCTTCATATGGTTCCCCAGTCTTTACATGTGGCATCCAAGAAGGGAAAGTATCCCCTCT
CCCTTGATGAGATGTCAGCCCCTCACCACACATGGCCTGGGTGCTAGGAGGACCCATACG
GGCTAGGGAGGGGCCACTGGGAGGGGAATGTGTAGGGGGCAGACCCCATCTAGCTGCTTC
TTGATGAGCCTGGCATGGAGTGTTTGATCCAAATCTTGACAGCACATTGGTGGCTGTTGT
CACTGTGTGGCAGGACTTGCAGTTGAGCTTCTTGTGCCTTGGACTTCTTGTGACTTGGAC
CTCAGCCTCCATTGAAGACCGTAACACAAGTCCCAACTTACAAACAAATGAGGGAATGAA
TGAGCTTTGGCATTGGAAAAACCTGGGTTCAAATCCTGGCTACTCTACTTCCTGTGTCAG
TTGCTTCACTTTTCTAAATATAAATTGTGTTCCTTCTGTTTTGGCTTCTAGGAAACCCCG
AGCCAAACGTATGGCCACCTCTGACCACTCGACCAGCCCAGCATGGTGTACATTTCTGGG
TAGCTTATCACGCCTTCCAAGCATTGCCTTTATCTTCCTTCTCCCCATCAAGCCTGTATT
GTTTTCCTTTTGAATCATAAGCACTTTTGTTAAATACCTCAAATCTTTCGAGAACAGCAA
GGAGCAAAATAAACTTAACTTCTCTGAGAAAAAAAAAAAAAAAAAAAAAAAA
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Cisplatin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Osteosarcoma [ICD-11: 2B51.0] [1]
Resistant Disease Osteosarcoma [ICD-11: 2B51.0]
 Disease Info 
Resistant Drug Cisplatin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation METTL3/LINC00520/ENO1/glycolysis axis Regulation N.A.
In Vitro Model 143B cells Bone Homo sapiens (Human) CVCL_2270
U2OS cells Bone Homo sapiens (Human) CVCL_0042
MG63 cells Bone marrow Homo sapiens (Human) CVCL_0426
HOS cells Bone Homo sapiens (Human) CVCL_0312
Mechanism Description LINC00520 was identified as a novel cisplatin resistance-related lncRNA in osteosarcoma, and its high expression was associated with poor prognosis of osteosarcoma patients. Functionally, LINC00520 could potentiate osteosarcoma resistance to cisplatin in vitro and in vivo. Mechanistically, LINC00520 bound to ENO1 and upregulated ENO1 protein expression by blocking FBXW7-mediated ENO1 ubiquitination and proteasomal degradation, thereby promoting glycolysis and ultimately inducing cisplatin resistance in osteosarcoma. Furthermore, METTL3 could stabilize and upregulate LINC00520 in an m6A-YTHDF2-dependent manner in osteosarcoma. This study proposes a novel lncRNA-driven mechanism for cisplatin resistance in osteosarcoma, and offers a promising therapeutic strategy for reversing chemoresistance in osteosarcoma by targeting the METTL3/LINC00520/ENO1/glycolysis axis.
References
Ref 1 Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):133-6. doi: 10.4103/0971-5851.158852.

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