Molecule Information

General Information of the Molecule (ID: Mol05871)
Name
SNHG16 ,Homo sapiens
Molecule Type
Long non-coding RNA
Sequence
GCGTTCTTTTCGAGGTCGGCCGCGTGGCTGGAAGACATGGCCACTCCAGTCGGTGTTGAG
CACGGCGAGCAGTCTCAGGCCTTTAGTGATGATGATTAAAGGTGGTGGCTGTGGCCTTGA
AAACAGTCATGTGAAAACTCATCACCTTAAGGTGTTAAGTGTAAGGATCTTCATGATGAA
ATTTCTGTAAATGGTGCAGTCAGCCTCAGTTTCCAAAGCCGGAAAAGGATCCTCTAGTAG
CCACGGTGTGGCAGCTGCTCTGAACCAGGACCTGGACCCGGACCCAAAGTGCCATGTCTT
TAATGTGAGTTAGCTCCCAGCGATGCCAGATGGGATCAGCACAGCCCTGCCTCTGCTGCT
AATTGTTCCTCTAAAGTAATCGCCATGCGTTCTTTGGGCTTCATCTTTAAAGGAATGAAG
CAACTGAGATTATTCTGGAAAACCTTTTGGCAGTTAGTGAAATTAGAGTACAACTAAGAA
CATTTTCAGACCTCCACTGTGGATGACCTGGGTATAATCTCACAAATCGATGGGACTGCA
AGGATTGTAAACTGAAATGAACATGATTATACTCTGTTGGAAGAGCCTAAGAGGAAACTG
ATGCCATGAGTTTCAGAGAGTAATGCTTAACCCCAGTTACACAGGATGCCGTCTTGTGTT
TCCTCTTGTTTAGTTACCCACTACAGTGATTTTGTGATCTGCTAATGGGTTGCCACCCAC
AACCATTGCTTTAGCACTTTTACTTCAAATCAATGAAGGATTGATAAAAGTTCTCCTGGT
GTCTCCGCAGAGTGCCTTCCAGGAACAGATCTTTGCATAGAATATCAGTGGTTTCCTTTT
TTGTTTCAAATAGTGGTCAGAAAATACCCAGTGTTGACTCACCAAGGCAATCAGCTTCCT
TTTTCCCTTTTTTTGTTTTTTTTTTAACATTTTATATTTTTGCTTTATTTTATTTTATTT
TATTTTATTTTATTTTATTTTATTTTATTTTTTGAGACGGAGTTCCACTCTGTCGCCAGG
CTGGAGTGAAGTGGTACAATCTTGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCAAT
TCTCCTGGCTCAGCCTCCTGAGTGCTGGGACTACAGGCGCGTACCTTCTTTAGTAGAGAC
TGGGTTTCACCATGTTGGCCAGGATGGTCTCTATCTCCTGACCTTGTGATCTGCCTGCCT
CAGCTTCCCAAAGTGCTGAGATGACAGGTGTGAGCCATCAGACCCAGCATTTTTTTTTTT
AATTTAAATTTAAATTTTTTTTCATTTTTTTGAGAGGTTTTTTTTGTTTTGTTTTGTTGT
TGTTGTTGTTGTTGTTTTTGAGACAGTCTTGCTCTGTCACCCAGGCTGGGAGTGCAGTGG
CATGATCTCTGCAACCTCTACCTCCCAGGTTCAAGCAATTCTTGTGCCTCAGCCTCCCAA
GTAACTGGGACTACAGGTGCACGCTACCACACCTGGCTGATTTTTTTTGTTTTAGTAGAG
ACAGGGTTTCAACCATGTTGCCCAGGTTGGTCTCAAACTCCTGAGCTCAGGCAATCCACC
CGCCTTGGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCCACCACACCCAGCTATTTTT
TCTTTCGTTTTTTAATTTTAAAGTTGGGGGGGGGTCTCAATTTGTTACCCTGGCTGGTCT
CGAACTCCCGGACTTAAGCGATCCTCTGGCTCCAAGCCCACTACCAGTCTCAGGTTTCTT
TACTAAAAGATCACTACCTTTTTTTCTCTTATCTGCTGCCATGTGAGATGTGGCTTTCAC
CTTCCGCCATGATTGTGAGGCCTTCCCAGCCATGTAGAACTGTAAGTCCAATAAACCTCT
TTTGTAAATTAAAAAAAAAAAATCACTATTTAAGATACTAGGATGGATTGTGACTGTTGA
GGAGTACTTACATATCCTACATTTGACTACATTATTTCCAAACCAAGTATTCCATCCAAA
GGAACATACTGCTATCATAGAGACCAAGGAGGGACTGTTTAAGGTTGCCAAGGTGAAGCG
AGCTGAGAGGCTTTGTCCTCGTGCCAGTAACTCTGAAATCTCTCTTAATTCCTGCTGTCC
AGGCAGCAGAATGCCATGGTTTCCCCAAGTAGGTAGCTGCTTTAGCAGTTAAAGCCCAAA
TGTCTGTTCTGTTGATCAGAGGTCTCTGAATTTCTGAAGTGGTGTTTCGTTTCTGGTGAC
TGAGTTAATCCTTTACAATCCCTCTTGTAAAGTGTGCTAATAGAAAGAATCCACCTTTCA
AAGCTGCAGAACCAGACCGTGCCCTAAATTGACCAACGTAACTGATGTGCCTCAGGAAGT
CTCTTGCCAGCTGTCCCTGTGAAGACCCCCCTCCTCCCCCCCAGCTGCTGCCTTGCACAC
TGAAGCATCTCAGACTGTGCAAAGCCGTGTAGTCATCAAGACAGTAAATCCCAGGGCTTG
GTTAAGTGCTGTGTGATAACTTGTTTGGATGAGACTTAACTTAAAACCACTTACAATAAA
CTTGGGAAACTACCGTCA
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Sorafenib
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
  Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Hepatocellular carcinoma [ICD-11: 2C12.0] [1]
Sensitive Disease Hepatocellular carcinoma [ICD-11: 2C12.0]
 Disease Info 
Sensitive Drug Sorafenib
 Drug Info 
Molecule Alteration Expression
Down-regulation
Experimental Note Identified from the Human Clinical Data
In Vitro Model HL-7702 cells Liver Homo sapiens (Human) CVCL_6926
Skhep1 cells Liver Homo sapiens (Human) CVCL_0525
Huh7 cells Kidney Homo sapiens (Human) CVCL_U442
Hep3B cells Liver Homo sapiens (Human) CVCL_0326
HepG2 cells Liver Homo sapiens (Human) CVCL_0027
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description RESULTS We found that SNHG16 was upregulated in HCC tissues and cell lines and that it was negatively correlated with survival time in HCC patients. Univariate and multivariate analyses revealed that SNHG16 was a significant and independent predictor for the overall survival of HCC patients. Furthermore, downregulation of SNHG16 inhibited proliferation, migration, invasion, and sorafenib resistance in hepatocellular carcinoma cell lines. CONCLUSIONS Our findings revealed that lncRNA SNHG16 could be used as an oncogene to predict the outcome of hepatocellular carcinoma.
References
Ref 1 Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancerMol Pathol. 2003 Oct;56(5):286-92. doi: 10.1136/mp.56.5.286.

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