Molecule Information

General Information of the Molecule (ID: Mol05601)

• Name: PSMG3-AS1 ,Homo sapiens
• Molecule Type: Long non-coding RNA
• Sequence:
  TCCGTCCACCTTCCGGAAGTCAGGGCCGCGGCGCTTCTGGTCCCGGAGACTTGGGGCTCC
  CGGGCTTCTGAGCGGCTCGGGTTCCGCGCTGCCGGCAGGGCTTGGGGGCGCCTTAGAGCC
  GAACCCCGTTTTTTCAGGAAAGGGCGCTGCGACCACCCCCGTCCCGGGCCTCAGCCCCTC
  TGCTGCAGACCCTCGGGATCGTCGCTGGTAGGAGCTCTGTCCCCCGTGTCTGTGTCCAGG
  ACCCCCGAAGCGCCGCGCCTAGGAACCCCCTAGCGCTGGGAGCCCGGCCCTGCTCGACCA
  CGGGCTTTGGGCTGGAGGCGTCATCGTCGCCACAGCGAACGCTTATTTGGCACCGAGTGT
  CCGCCAGGCATCGCTCTAAGCGCTTTATACCCATAACTCACTTCATCTCAGCCACCCGGT
  TCCGTAGAAGCGTTTCATCCGCGTTTTACAGACGTGTGCAGGAAAGATTCTGAAGCTTGG
  CGGAGAGGGGTGTGTGAGTGGACACCAGTGAAGTAACGGTTTTTGTGTTACGATGATTTC
  TGTTTTCCTCTGCTGCCCTGTAATGGCAGGAACTCGGATAGTCTGGTCTTCAGACCAGGA
  GGACTCCCAGGAGAGAACGGAGAGCCAGTGTGCTGTGTGTCACGGTCCCTGGATGAACGT
  TTGTGGAACTGGATTGAATTAAACAAGACGTGCAAAGCAAGTGGTTCACGAGATTCGATT
  GCTGTAGGGACCCCGTGGGTGTGGAATCAGACAGTATTGGTCCTTTCATGACTGGCTTAT
  TTCACAAAACCCGATGCCGTCGAGGTCCATCCATGCTGAGATATTTACGGAGCATCCCCA
  GCTGCTGGATGCTGGGACCCACCAGTGGGCAAGAGGGCCGTGCCCACCCCTTCCTGGAAG
  AGACACTCACTCAGTAAATGCAGAGATTCAGTGTTGGGGTAACCCCAGCACACAGCCCTG
  AGGGAGGAAGCCCAGTGATTTGATCGGATTTGCTTTTCTCTTCTGCCTCGGATTCTGTCC
  AACCCCTGGAAGGACCTCTGAGGTGTCCCGTGGCTGGTTCTAGGCCCCATTCAAGCCTCC
  TCCTCCAGGAAGCCTTCCCAGTCCTGGGCATCTGTAGCCAGCTCGGTGTTTCTCACCTGG
  GGCCTGGGACGTCTCCCATTCTGAACTGCCGTGTTTTGGGTTTACTGTTCTCTGGCTTTT
  GGTCCCAGCCGGACGGTGGCCTCTTGTGTTCAGGGACAAGGCAAGGAGCATCCATGCACC
  CCCACAGTACCCAGGCTGGGTCTGTGCCCGCCAGGCCCCCGGCAAAGCTTGGATGATCCG
  GGCTGGGCTGTTCTCCTGCTGCTCTCCTGCTGCTGGCCTCGCTGTATCAGCTGATGGCCA
  TCGCGCCTCCTGCACCCGTCATCCCGCCCTGCACGCCCCCGCCACGTGGATGAGCTCCCT
  GGGGAGTTAATGGCTAATGGAGTCTCCGCTCTCTCTTGTCAAATGCAGCCATCATCCGCT
  GGTGCTTTAAGGGACTCTCTCCCGTCCCCACCCTATTCTCAGGTGGCTCCTACCGACACC
  ACCTAATGGTGAACCCCAACACGAGGACACAGGCAGTGCCCTCTCAGGACCACTGTGGGT
  GCCACCAGGCACGACTTCCTAAACACCCACAGAGCAAAAACCTGGAAATTCAGCCGAGGC
  ACTGGGACCCCAACCTCTCCCAGAGTGGCCCCAGCTCCACGGCGTCTGCATGGCTCTGGC
  CGTGAGCAGAGCAGCCCCGACCTCCGTCCTGACCCAGGGCGCCGGAGCGCCACTGCGGAT
  CTCACCACCACACAAGCCAGACCTGCTAGGAAGCCCTTCCCGGCCACCAGCTCTCGGGCG
  ATGCACACAACAGGGCCTTTTGAATTCCCTGAGGTTAAGGTTCCCCTTGAGTCTCCTGGG
  CTACAAGCAAATCCCCCGAGGGGAGAAGTCCAGGCTGACACAGCCTCCTGCACCCCTGCC
  TTGGGAGGCCACACCTCGTTTGCCTCTAGAACCGACGACTGGGGAGCACTGTTTGCAGAG
  TTCTCTCTCTCTGGAACGGTGAAGGAATCTGAAGCCCAGAGAGGGAAAACAATGCCTCCT
  GGGTCACACAGCCCATCAGGGGCAGGGCAGGGACGAACGGCGAGAAAAGGACCAGCGCGA
  GAGGAGATCCCCAGCAGTGATTCCTCAGCCAAGCCCAGCGTCTACCCACATCCACACCTC
  ACAGCCACCTGATGGGGAAGGCACCATTGCCCCTTTTCAAAGGTGAGAAAACAGAGGCTC
  AGAGAGGTTCAGCAACTTCTCCCACAGCTACTTCGTTGTAGAACTGCAGTTCCAGGTGTC
  CCCGAGCTCTCCCTTCCCGAGCCATCTGCTCCTGCCCTCCTATCCGAGCCCTGGCCCTCC
  CAGTCAAAGCCGGGTAGTGGCTGTTCAGAAGCCTTGGGGCTAGTCAATCCCAGCTGTCTC
  GGACCAGGGCCCCCCCCAGGAGGAGACCCTGAAGGATGCAGTTGAGAATATGTGCTTTCT
  TTGGTAGGTGATCTCAGGAATTGCAGGGGAAAGAGGGGGAGCGTGTTAGTGTAGGCTCTC
  CGGAGAAGCAGAACCAACGCACAGAGGAGATTTAGGATGAGGAATCTGGTTTATGTGACT
  CTGGGGGCTGAGAAGGCCCACCATCTGTGTTGCAAGCTGGAAACCCAGGGAAGCCTGAGG
  TGTGATTCAAACTCAGCTCAGGTCTGGAGGCCTGAGAACCAGGGCAGCCGATGGTGGACA
  TCCAGTCCAGGGGCAAGAGATGACGAGATGTCCCGGCTCCAGTGGCGAGGCAGGAAATGA
  GGGGTGAACTCCTCCTCCCTCTGCTGTCTGTTCTATTCAAGTTCTTGAGGGATTGGATTA
  TGCCCAGCCACTTGGGGAGGGCAGTCCACCTTCCTGAGTCCACAATTCAAATGCTGATCT
  AATCCAGAAACACTCTCACAGACACAGTGTGTAGTCTGGGCACCCCACAGTGCACTTAAG
  TGGACACATAAAATTAACCATCCCAGGGAGTGAGATGGGTAAGGGAAGATGGGCCACAGT
  GGGTGTGTCTCCATGCCTACCCCCACTGTGGGCAGCTGCTGGAGCACACGCCTCAAAGTC
  TTCCCTGAGGGAGAGGGAGCTGAGGTGTTTATATCCCAGCTCTGTCAGGCATTGGCTGAA
  TGTCCACACTCCTGGATCACCGCCTCTCATCCTCATGATGTCCCATGGTCCTCATTTCAC
  AAGTGAGCTCTGGGTACATGGGGAGCATCAGTCACACCCTGGGTCAGTACCTCAGCTGTC
  TCTCACATGACATCCTCATTATCCACACTGCAAAGCCAACCATCCCTATGATGGGTTCAT
  TGTGGATCATGACTTAGTGGGTCAAGAGTTTGGAAGTGGCTCAGCTGGGCGGTTCTTCTG
  CTCCATGTGGCTGCCAGATGGTACCCTGCTGGTGGGCAGTCTGGTCTAGAGGGTCCATGA
  TGGCTTTACTCACATGCCTGGCATCTTGACAGGGACAGCTGGAAGGCAAGGTTCAGCTGG
  GACTGTCCACAGAGCTCCTCCCTGTGGCCTTTCCAGCATGGTGGTCTCAGGGTAGCTGGA
  CTTCCTGCATGACAGCTCAGGGCTCCCAGAGCTACTGTCCCAAGAGATAGAAGGTGGAAA
  CTGCCAGTCTCTTAGGCTAGGACCAGAAACCAGCACCCCTGCACCCACAGCCTTTTGGTA
  GTGATGAAATAAACATAAGATTTATCATTTTAATCATTCGTAAGTGGGATTAAATACATT
  TACAATATTGTGTAACCATCGGCACTGTCTATATCTAAAACTTTTTCATCATCTGCAATA
  AAAACTCTGTATGCATTAAAAAAAAAAAAAAAA

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Temozolomide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Brain glioma [ICD-11: 2A00.02] [1]

• Resistant Disease: Brain glioma [ICD-11: 2A00.02]
• Resistant Drug: Temozolomide
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HEK293T cells; Kindey; Homo sapiens (Human); CVCL_0063
• Experiment for Molecule Alteration: RT-qPCR
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Here we show that the long noncoding RNA (lncRNA) PSMG3-AS1 is significantly upregulated in GBM and its expression correlates with the grade of glioma, with the highest level observed in GBM (Grade IV glioma). We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. Mechanistically, PSMG3-AS1 directly binds to c-Myc and thus stabilizes c-Myc in the nucleus to promote the survival of GBM cells under treatment of TMZ.

References

• Ref 1: Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):133-6. doi: 10.4103/0971-5851.158852.