Molecule Information

General Information of the Molecule (ID: Mol05557)
Name
MAGI2-AS3 ,Homo sapiens
Molecule Type
Long non-coding RNA
Sequence
GAGGCAGGCTGGGTCCGCCTGGCAGCCTACGGGAGGAGGCGGGAGCCGGGAAGGAGGGGA
GCCTAGGCCCGGCGTGGGGAGGCCGGCAGGAAGGGCCTCGAGCCCAGTGCGGACCTTTCT
TCAGCCTCTGTGCGACCGAGCCGCGCGCCAGGCTCCTGTGCGAGGAGGACGCGCTGACTC
CCTCCGACCTGGGCTCCGATGGAGCAGAAATAGCGGGACCTGGACTTGTGGCGCGCCTGG
TGCCACATCTCGGGCTCTGCGAGCGTCCTGGCGCGGGATCCTGCCGTTTGCATCCAAGAG
AGGGGAGGACAGGGGCAAAAGGATGCAGGGAGGCTGCTGATTTCCACTGAAGAGCTAATT
TCCTGTGAGACATTAACAGTGATTTAAGAAAAAGATTCCTGTAACTGTAATGTCTTACAA
TAACAGAATGCAGGAGAGCACATATCAATGAAGAAAAGACAAAATGTACTTATCCATGAA
GCTGAGGTTAAGAAACCAGTGTCTTCAAGAGCCAGGGACAGCACTGGGTCTGTGCAGAGT
TGAGAGATGGTGATGACATGTGGTTTCCAGCATTCCTCACCCAGTCCAGGGACACTGTGG
GTGTGCCCAGCTTAAGTCCAGTAACTGGAAATACAAGCCCAAGTTCTGGAGAGTTTGAGC
TGCAGAGATATATATGGGAACACTTTGAATCTTGACTCATTGGCCATAACCAGCAGAGTG
GAAAATACAAGAAGAGAAAAAAACATTGAACTGCGATTTTATAACATCCTTTACTAGGCA
GAGAGAAGAGGAAACACCAGGAAAGAAAACTGTATTACGATGTGAAAACTTAATGTTGAG
AAATTCAGGCATCTTGGGGTTAGTGAGGAGAAGTTTTAGGGGCTTAGATTCTTCTAAACA
CATGTACAGAAATGCATATTTCATCTGATATCAAATGGCATTTATAGTGCTAATCTTTAC
CTCAAGACTTCACATCTTTTGGTGATTGCATCTTTTAGGTTTATAGCAGCTAAGTTTGCA
TGAAAACACCAGGGCTGTTTCATTTCAGTCAAGAATTAATGTTCATTGATTGTGCTTCTG
CATTTCATGTAACTATTGTAGAATTTGTTTTAGTTTTATGAGGGAATAATTGTTCCAACT
TCTATATAACTCAGGAATTTACTCTCAAACAACACTGTCAATTAGTTACTTATCTCTCTG
GAAATGATCTGGGAACATGGAGAGGAAAGGGAGGAAGGGGCAAAATCTGACCACTTAAAT
CTAAGCATATTAGATCATTTTATGCTAGAAAGTCCTGAATGATGTGACTTTCGTTCTTGT
AAAACACCTCTTTCCATAGATTCATGGCCCAAACAGTATATAAAGAGTGGGGAAGGAACT
GCATTTGCAAATAGTTCAAATCATTGCTCCATCTTAACTACGCAGTTCACAAAGTGTGAA
GAAATGTGATCATCTCAAAAAAGATAATGGGGAAAAAATATGTTTTGTTCTGTGACTTTA
AAGTCTTGCAATATTTTACATAAATGATAATGGGTGCTTTAATAAGAACTCTTGATACTT
TTGTTATTGTATTCAATATATGCATATAATACAACAGGATGATATTGTTTTGGATTTGGA
AATGTATTCTTTCTTATGCAATCTTATGCAGTCATACTGCTTGAATATCATTACCTGAAT
TTATCTTTCTTTTTTTTGTTGTTGTTTTACACTCTACTTATTTGGTGCCTGTCAGTCTTT
TGTCGTCAGTTTATATTCTACTAAACTCAAAAAGACAATCTCATACCTTTTGTAATTGTA
GGCATTCTTTACTAGATTTTTAAATACACTTCAAAAATTCAAGTACTTTGATTTCATGCC
ATCAAGTAGCTGAATCTATCCCCCCGTCTCTTTTTAAATTTAAGTGAGTAGTTCAATTTC
TGTCACTTTCTACTTTGTGAATTCTAAATCTTTTAAAACCATCTTGCCATTTTTCGTGCA
CTTACCCTTACAGAAAACTCTGTGAAACACTACTTATCTCTACTTTTATGTTTTTAACTC
CTTTTTTATATTACTATTCCCTCTGCTTTCTAAATGCACATATTAATTTGTTCTTTTTAT
TCTCTGTAGCTCTTCTCAGTGTATGAATTCAGTTTCCCATCAGTCTCCATACAATTAAAA
AAAAGTTGAGTATTCTGTTATTTTAATAAGATATCTAGTGCCCATATTCTAATTCTGCCC
CTTATTTTTAATATAATTTTATTGTTGATTTAAAATGACAACAGTTTCAATTCCCAGAAA
GTGAAAGGAAACAAAGGAATAATATTATAGGCTTAATTTTTATCAGTGAACTTGTAGGTG
AAGAAAAGATTTGGGGAAGGAAATGAACATATTATATTGCAAAATAGTAAGGAACAATCA
GATGTGTTTTCTAGTCTCTGGAAAAGCATGTTTCAAGAAATTCAATGAAAAGTTCATCAT
GCTTGCTTAGATTGTTGAGAAGCAAAAACACTGATGAACATTTGGAAGCAATGAGAATGT
AATTCTAATCATACTCTTTTAATAATGTTGCAAAACTCTCCAAACACTACTCTGTGTGGA
TGTCTTTCAGAATATGATGAATACTAGTAGTCTTATTCTGCCCTTTTCTCTCTATCACAA
TATATACATTCTATATTGCATACACATATTTTCCAAATATTACATATAATTTCATGTAAT
TTATAGACCTATTAAGGCCCAACCATTTTCTTGGATAGGGGATTCTTTAGAAGTCCAGCT
TAAATAAAGCCCGTATAGAAAGTTTTTTTAAAATTTATACATAATCACCTAAAGTAACCT
TATCTACTGAACTCTTAGTACATGCTACTGGAACCTTTTATCATGTTTCTTCCTGGCTTG
CATTACAACACTGTTGACATATCTCAGCCTTACTTCTAGGCTTCTTTGAGAGCATGACTC
ATGTTTGTATTCCTCACTGAGGTTGAATGAATAAGAGAAACTACAGTAGTAGGAAAAAAC
AGTACATGTACATATCAATGAATATGAAAGGGTCAAATGGATCTATTATAGTAAGCACAA
AATCAACTGACACCAGCAAAGTAAACCCAAAATTTTTAATGGTATTTTAATAGATCAAGA
GGAGCAAGCAGATTTTTGAGACAGTTGTCTCCTACTTTCTCTATCACAGGGAGTAATTTT
AAAAGAAAAATGGAGGGTAAGTTTCTTTAAGAGAAAATTGTAGTTTAAAACAGGTCATGG
GATAATTAGAAATAATTTAATTTCTTTAGAGGATTTTAATCTTTCAACTGCTTGCAATTA
GATCCTAAGGCAATAAAAGAATAAGGAGATTTGGAAAACCATTGTCTGTAATCTCTGAAG
AAAAGTGGACATTAGGGGAGTCAGTTGAAAAGCAAAGCTATCACCATTTTCTAAAGAGGA
AAAAGGTGAACCTCACAAACTATAGACCAAAAAAATAGGACATCGAGAGAAAGAATATGA
AGCTAGCATAGGTTCACAAAGAATGAGTCAAATCAAACAACATGCATTTTTTATTTATAA
AGCATGACTTGTTCATTGTCAATTCATGTTAGCTTAATCATTAGGCATTAATGCCATCAC
TGCAATGCATATGTCAGCAATAAATAATCAAAGACCAGGCTTCCATCATTCTGTTTAATA
TCTTCAAGTAATGCTTAAGTTTGCAAATGCTCTTTTAACACATTCTCCATATGCAGCCTG
CCCAGCACTGCACACAATAGACCTGTTACTTCCCCCTCACGAGCACTCCTAATATTTCAT
GTGCTCATCCAATTGACTTCTCCCACTGGTGCCTCATATTGAATTTGTAGAATCACACCT
GCTCCTTTTTCAAAACTCTTCTGAGTTTTTTCTTAAATAATTCACTGACCCCAAAGTTGT
CAGATATTTGAAGACTACTCGCACAATTTTAATATTATAAATGTATAATGTAAATGTAAT
TAAGATTTGTATAATGTACGATGTACTTTGGTAAATAAAAGTATGCTGTGAATAAATACG
TATGATACAATTCAAAATTTTACATAAATATGTGATAAAATTTAGCTCATATTCTTTTTT
TTTTTCTTTGAGACGGAGTCTCACTCTGTTGCACCCAGGCTAGAGTGCAGCAGCATGATC
TCAGCTCACTGCAACCTCTACCTCCTGGGTTCAAACAATTCTCCTGCCTCAGCCTCCTGA
GTAGCTGGGATTACAGGTGCCCGCCACCATGCCCAGCTAATTTTTTTCTATTTTTGTTGT
TGTTGTTGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCC
TGACCTCAGATAATCCACCTGCCTCGGCCTCCCAAAGTTCTGGGATTACAGACGTGAACC
ACGGTGCCCGGCCTAGTTCATGTTCTTTAAGGACAATTATGAATATTTTTATGCACTGTT
AATTTTCATTAAGATATTGATCAATTAATAGCTATATATGTTCTATAAATTAATCCTATC
TAGTTTCAATCTTAAATTGTTTGCATATACCAATCTAGTTTATTGTTTGCATATATTTTA
TAGTGTAGAGATTAGGCATTTTAATAAAATTTTAAAATTTCCAGGACATACTGTTAATGA
CTATGCTTCCTACTATAGGCCATAATTAATTTTTTTCTATTGTCAACAATATTTTGGTAG
GGATGATCAGGAAATAAGGAAATGTTTCCTTCATTTGTTAACAATAGGTGTTTGGGGATT
TTAAAATGAAAATTGAAGAAGTAAAAGACACCATATATTTAGTTTGTTTGATTTCGTGGC
TTCAAGAGTTCAATAATTTATTGAAATATTTTACAGACCAAAGAACAACAGATATATTAC
GTTTATAAGCCCCCACATATTTTAAAGGATAATGGTTTATATATGAAAATTCCCTGAACC
TACACTTCATCAGGAAAAGCTAAATAAAAGAAGTTTACATTTCCTAGGACTAATGGAGAT
TTATTTCCCAGTCCTCTTCTCTGGAGACAAATGTAGGTCTCTCTTGAAAAGCAGAAAGTT
TTGCATATGAGGTATGATTTAGTGGGCTAGAAACATCTTTTCCACCCTCCCCAAAATGTT
TCACTATGTTTTATCATACTATCTGATAATTTTGCACTAAAGTTTTCTTTCTGTGTTAAG
AAAATGCAAATATCTCTGAATGGGTCTCTTTGCTTTAGTCATACTCATATGGCTACTACT
GAACAAAATATGTTCATTACAGGATGAAGGGAATGTTGCCAGCCAGCAAATCCCTAGAGT
TTGCACTACACCAAACGTTGCTTAGCAATTTCCACGATTTTCTCAGTCTAATTTGCAAGA
ATCAAGGAGATGTTTGTGTATGCTACATGAAGTTGTAAAATTGGTATTTATTGTATGTTT
CTATATCGAAAGCTTTACAAACAAAGGAAATGGAAAGTTAACAGGTGGATATGATAGTGT
GGCACTACTTTAGCTGGATGGTAAGGGAGAGCTTCTCTTAGGAAGTGTTTTAGGCCAGGA
CTTGAATAATGAACAGTATCTAGTTGTACAAAAATCTGGAGGAAAGACTTTTCAGGCCCA
GGAGAAATGAAAATTCTTTTCATGCATACAAGAATGAAAGTGAAAATTACCTACTCTATG
TCCTGAAGTGGGAAGTTGGCTTGCCAGAGAGTAGGTAATTTTCACTTTGATTCTTTCATG
CCTTCAGTTATACTACTTCTTAGGTTAGTTCATAAGGGTTTCCACAATTTGGTTCCCACT
TAAAATTTAAAACTTCCCTAACCCATTCCCACCATATATTGTGCTAATCCATGCATATGT
GACTTTGCGTATGCTGTTTTCATTGTTTAATATTCTTCTCATGCATTCGTTCTTTCCTGA
TAACGAACTCATCTTTGAAACTCCCCTTCAAGCATCCTCTACTTTAGGAGGCCGCTTCTC
ACTGTCTCCTGCCTACCACCCATTGAATTGTTCAATTTTTAAGCTGCCATTGTCTTGTGC
AGTTGACACATTTCTTTGCAATTACTGATTTACATGTCTGCTTTTATCACTGGTGAGGTT
CTTTAGGACAGAGACATTATTAATTCATCTCTGGGCACATATGTTCCAACATATTAGAAG
TACTACAGAGTGCTATTACTATGTAGTATGTAGTATTAGTAGTAGTTACTCACAAATCAT
TTTTAAATAAGTGATTATAATATCTTTTTGTTATTATGATTTAACACAAGATGGAATTTA
TTTTCAGAAGTTTCCATGATATATTTGTTCTATTTAAAATCCAATAGCCATTAGAATATT
ACCATTATTTAATGTAAAACAATAAAATATTAAATATGATCGTTCATATTTAATGCAAAC
CGAACTCATGGAAATATTGTGTAAAGATCAAGTAATTTTTGACATACAATTTTAAACTCA
ACTTTTCATATAGCATACCTTATGATATATTTTCAGCCTACTTTTAAATATGTTGGCATT
GAAAGCCAGTTACTAATTCGCTGAATTCATGATTTCTTTTTAAGTTATAGAAGTGGAATT
ATGTTTGAGATATTCATTGCATTACATTTACCAGAACTTGAGTTCTTAACATGGAACCTG
AGAGTTTCTCCAATTCTTAAGTCCCTGGGAGAAATAGATTAGCTGGATGAGGAACTGAGA
GGAAAAATGGTCAGAGATGTAGCAAGAGTTGGGAAGAAGGAACAATGATTTGCTTTCAAG
GAGATTTTTTCATTGGTCTGTTTTCAGTGACAAACCCACTGCGATAATACATGTAAAGTG
AAAACATTCAGGAAGTTCCCTTAGAAACCTCTTTTCTGGCAGTTCCTAATTCTACAACAT
TGTATAAGTGAAATACCATAGTTACTGTCATAGTAAATTGAGCCAAGAGAAACAAGGGAG
CAGGAGAAGAAAAGAATTAAAGAGAGTTTTGTCTTTCAGTCTTCACTCTGTTTCTTCTTG
CTTTTACCAGTCATTCAGGTTTATATAATTTCTTTAGAGAGGCTTCTACTATGCAGGTCT
TCCTTAAAGTCATTGGTATTACCTGGCATGATATGTGAGCCTTTAATATCAGTCCCTTTA
TCTCTTTATTTTTAAAGTTTATATCAGTACAGAGTCCTGGATTCTTAATTAATTTAATAG
GTTAGACTTTATGCTAATATTCTTCATTTTGATGCTCAAATTTTCCAAAATTTGGCCAGC
AGGGTTCCTTAAAGCTGGGTACCTTGCCCTTTCAACATGTCCCTCTGATTCTTTATTTTT
ATTTACTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTAGAGACTGAGTC
TTGCTCTGTCTCCCAGCCTGGAGTGCAATGGCACAATCTTGGCTCACTGCAACCTCTATC
TCCCAGGTTCAAGCAATTCTCCTCCCTCAGCCTCCCGAGCAACTGGGACTACAGGCATGT
GCAACCATGCCTGGCTAATTTTTTTTGTATTTTTAGTAGAGACAGGCTTTCACCATGTTG
GTCAGGCTGGCCTCGATCTCCTGACCTCAAATGATCCATCGCCTCGGCCTCCCAAAGTGC
TGGGATTACAGGCGTGAGCTGCCACACCCAGCCGTCCCTCTCATTCTTTAAGTACTTCCA
TGTTTTCTAAGGTACAAGATGTTCCATATTATTTTGTTATTTGTCTTCCCCAGCTCTGAA
ATCTGCCTTTCCTTCAAGGAGCCTTGGTTCTTTCTAGTGACAAATTATATTTAGAAAGAA
GATCTGGGTATTTGACTTGTATATTGCTATTAATTGGCCATTGTTTCTAGTCTCTTTCAG
TAGACAGAGCTAAGAAATGTAAAAGGAAATATTTGAATGTATGTATATGTGATATATTAA
GTACATTTAAACATATTAAATTCATGAGTTCATACTAATACTTTCAATAAGCCACAATTC
CCTTTTCATGTTTTCGAAGGAAAAATATCCATTGTCTATATACAGTGGACATAGATAGTA
ATAATACTGATCTTGAAAAGAGCAGTCTTAAATAGATCCCATTAATAGTTAAAGATAACA
TATCTTAGAATTCTAGATATTAGAGAGATTATCTAGAGCTGTAATCTAGATATTTTATAG
ATCTTTGCTGTGCTGTTTTGAATTTGTGTTGGAGTAGAACAATCAGATGACAAAAGCTCA
TCCCACATGGAAAAATCAAAGCATTCATTACAGAGAGAATTTTGAAATAAATGCATATAT
AAAAAATATATATGCATATATAATGCATATGTATATGCATATAAAATATATATATATAAA
ATGAGGGTTATAAACAATGAAGGAAATAGTGATACTATCTATGTGGGAACAATACTAGTA
TCCTCCCTTTGGATGAATACAGTAGCTACAGATGCAATTCTGGGGACTCTGTTTAGCAAT
AGCTTAACTATTGCTTGGCTACAAGCATGGATAACTTGTTCAAAGATAATGAGGAGTTGT
AAATATTTAAATAAACAGGATTTGCAACATAAAAAAAA
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Temozolomide
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Brain glioma [ICD-11: 2A00.02] [1]
Resistant Disease Brain glioma [ICD-11: 2A00.02]
 Disease Info 
Resistant Drug Temozolomide
 Drug Info 
Molecule Alteration Expression
Down-regulation
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation AKT pathway Regulation N.A.
In Vitro Model LN229 cells Brain Homo sapiens (Human) CVCL_0393
U87 cells Brain Homo sapiens (Human) CVCL_0022
Experiment for
Molecule Alteration		 RT-qPCR
Experiment for
Drug Resistance		 MTT assay
Mechanism Description MAGI2-AS3 was expressed at low levels in TMZ-resistant GBM cells relative to that in their parental cells. MAGI2-AS3 re-expression alleviated TMZ resistance in TMZ-resistant GBM cells. MAGI2-AS3 overexpression also accelerated TMZ-induced apoptosis and G2/M phase arrest. Mechanistically, MAGI2-AS3 overexpression reduced MDR1 and ABCG2 expression and inhibited the Akt pathway, whereas Akt overexpression abrogated the reduction in MDR1 and ABCG2 expression induced by MAGI2-AS3. Moreover, activation of the Akt pathway inhibited the effects of MAGI2-AS3 on TMZ resistance. MAGI2-AS3 inhibited tumor growth and enhanced the suppressive effect of TMZ on glioma tumorigenesis in vivo. In conclusion, MAGI2-AS3 reverses TMZ resistance in glioma cells by inactivating the Akt pathway.
References
Ref 1 Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):133-6. doi: 10.4103/0971-5851.158852.

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