Molecule Information

General Information of the Molecule (ID: Mol05456)

• Name: LINC01198 ,Homo sapiens
• Molecule Type: Long non-coding RNA
• Sequence:
  CTCTCGCCTGCCTTCGGCCCTTAGGCTCCGGGAGATTGCAAATAACCTGCTTTCTTTCTG
  TTCCCAGGTGGCGTCGGACCCCTGTCAGAGAGTAAATCTCAAGTAAGGTACCTGCCATCG
  GCAGATTTGAGCTTTCTTCTTGGACACCTAATACCCACAGTCCTCCAGGCTCCGGTAGAC
  TGCAAATGACCTGCTTTCTTTCTGTTCCCGGGCTGCGTTTGGACCCCTGTCGGATAGTAA
  ATCCCAAGCTCCGGTAGACTGCAAATGACCTGCTTTCTTTCTGTTCCCGGGCTGCGTTTG
  GACCCCTGTCGGACAGTAAATCCCAAGAATGGAACAGATAAGAAGATACTGAAATTGGAC
  GGTGCTGCCGTGCGGCTGCCGCAGGACACCTTTAATATCCCTGTTTCTCAGGCTGTAGAT
  GAAGGGGTTCAGCATGGAGGTGATCACCGTGTACATCACTGAGGCCACTGCAGCCTTTCT
  CGGGGAAGATGACACATCTGAACTGAGGTACCCTCCAAAGCCTGTTCCGTAAAATCAGCA
  AACAACTGACAGGATAACTTCAGGAAGTGGGTATTAATTCTCACGGTATAAGTGAAGACA
  TTAAGCACCAGAGTTTAAGTAGCTTGATCCACTGAAAGAGATTCAACTGTGTGGAACCTA
  TGCCGTGGAGAATTGCTTTCTGCCATTGTTATCGTCCAGCAGTTGCCGAATAGCTCTGAC
  CTGAGCAAAGCAGTGAAACGCGGTGCTGTTGAGTGGGTTGCCACTGCACCTTTTTCAACT
  ACTCTAGTCTTGTGGAGAAAATACCCCTTCTAAATTTTTTCTTCATTGAATACTCTCCCT
  CAGCTCCAGAGTACCATATAGAGTTTTCTTGTATTTTAGAGTTACTGTTTTATCAAAGTT
  TACCAGTCTTTTGTATTACATTTCTCCTGTCTAAAAAAAAAAAAAAAAAAAAAAA

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Temozolomide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Glioma [ICD-11: 2A00.02] [1]

• Resistant Disease: Glioma [ICD-11: 2A00.02]
• Resistant Drug: Temozolomide
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: U87 cells; Brain; Homo sapiens (Human); CVCL_0022
• In Vitro Model: U251 cells; Brain; Homo sapiens (Human); CVCL_0021
• In Vitro Model: SHG-44 cells; Brain; Homo sapiens (Human); CVCL_6728
• In Vitro Model: SNB19 cells; Brain; Homo sapiens (Human); CVCL_0535
• In Vitro Model: LN229 cells; Brain; Homo sapiens (Human); CVCL_0393
• In Vitro Model: T98G cells; Brain; Homo sapiens (Human); CVCL_0556
• In Vivo Model: Nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: RT-qPCR; RNA immunoprecipitation; RNA pulldown assay; Western blotting
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Mechanistically, NEDD4-1 (neural precursor cell expressed, developmentally downregulated 4, E3 ubiquitin protein ligase) and phosphatase and tensin homolog (PTEN) were recruited by LINC01198, which functioned as a scaffold. Moreover, we showed that LINC01198 exerted its oncogenic activities by enhancing the NEDD4-1-dependent repression of PTEN.

References

• Ref 1: Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancerMol Pathol. 2003 Oct;56(5):286-92. doi: 10.1136/mp.56.5.286.