Molecule Information

General Information of the Molecule (ID: Mol05439)

• Name: LINC00942 ,Homo sapiens
• Molecule Type: Long non-coding RNA
• Sequence:
  AGGCTGCCTCCGGCTTCACCGCTCCTCCCCGAGCACAGCCTTTGTGGGGCCTACGGGGCA
  GTAGGAGACAGGACGCTTGTCCTGCGGAATGGCAAGGAATCAGCTCTCCATTTCAGGGCA
  AAGTGGGGCCTGGATTGTGGGCCTTGAACATGAAGGCAGGTGGGCGAGGGACTAGGGGAC
  CGCGTGAGGCCCGACGTGCACACGGCAGGGCCCGGCACCCATGGTTGCGTTCGGTCGGCC
  TTGGCCGGCTGGCTCCTGCTTGGAAACTTGCTGGGTGGTGTCTGCGGGAAACAGTACTGA
  GTCTGGTGAGGAGGCAAACGCTCAGAATCTACTGCAGGTGTTAGTTCTGCAGAGGAGTCT
  TCCTGCTTAAGGGCTCATTTGATGTTCTGGAAATTTGCCAGGTACTGAAATACAGCCAGT
  CTTCCCAAAGATTCCTCCGCTCCTCTGAGTGCACGTGTGTGTGTGTGTGTGTGTGTGTAC
  AGCCACACAACCTGACTCTTTGTTCACACACACGGGCCCTGGCCAAGTGTGAGGGTCTCC
  ACGTGACGAAGGAAATGAGTAAACAACTTCAACATTGTTGTTTCCCTCTGAGGCTTGCAA
  AGAAGGTGTTAAGAGCACAAGATTTAAATCATAAACTTTATTAAAAGCCAAACAGCCCAA
  TGTGCGATTCTTGCCAACTTGGACAGAGTCTTTGGGGTAATGCTACACGGAGCTAATCCA
  GAAGGAATCGAGTGGAGGAAGACAGCAGGGTGGGGGTGAGCCCACGCGTCCAGCCAGGAG
  AGGCAGAGGGAGGCACAGCCCCGACACAGCCACCCACCCCGTGGCCAGAGCAGGGTGGCG
  CAGGAGCTGGCAAGACCTCTAAGCTGTTCCTGCTTCTGCTCTCCTCACACTGTTTCCTTA
  GCAAATGGAGCCTCCTTCACGCCTAAAGGGCCCAGAGCAAGGCAGGGGGAGGAGGGCCGA
  CCCCTGCAAGACTGAGAACTGGCCAGAATTGCCCACTTGCTAGACTAGCAAGAGAGCGAA
  GTCCCAGTGGGTACCCCCGACGAAGGACACCCGTTCCTTACCCCCCACCCAGAGGCACCC
  TTCCTCCTCCAAACACAAGATGCTGCTCCAGCAGGGGCAGGGACCATGTCAGCCTCCCAC
  AAGACACACACGGGAAAGCCCTGCTTGTGAGGGCGCCACACCCAGGGCAGGAATCAGAAT
  GAAGACACGACTCCACAGTGAGCACGGGGCTCAGGACAGGACCCAGCGTGGCAGACCAGC
  CAGAGAAGCTTTCACACTGCAAACAGCCCGCTCCACCTACACCCCGACTGGGCTCCACGA
  CTCCCCGCAAGTGCCCTGCCACCTCAGGCACCTGCCCCCACGCCCACTCAGCGTCACCCC
  CTCGGCGGTTCATCTCCAGAAGGCTTGGAATTGATGACGTTTCCGCACCACGAGGGGCTT
  TTGCGATTCTGCGTCACTGAACTTGCATCTCATCCCCACGATCCGACATAAGCTTGCCAA
  GGACAGGACCTCGTGGCACCCGGGACAGGGGCCACCCCATCCTACATGTGACAAAGCTGT
  CCCTCCGTGGAGCTGGCGTCTCTGATTTCCTCGGCCTGAGGGAGGCAGTGAAGATGAAGG
  AAGGAGGGAGGGCGCCTTGGTGGTGGGTGCAGCTCTGTGCTGGTCTTTCTCTGGCCACCT
  AGACTTCAGTGGCCAAATGGCTTCAGGAGACCCACTGGTCTTTCCTGTTTTATTTTATTT
  TTTACTTTTTTTTTATTTTTATTTTTTGAGACAGAGTTTCGCTCTTGGTGCCCAGGCTGA
  AGTGCAATGGTGCCATCTCAGCTCACCGCAACCTCTGCCTCCCAGGTTCAAGCAATTCTC
  CTGCCTCAGCCTCCCAAGTAGCTGAGATTACAGCCATGCACCACCACGCCTGGCTAATTT
  TTTGTATTTTTTTTTTTTTTTTAGTAGAGATAGGGATGAGCCACCGCGCCCAGCCAGTCT
  TTCCTGTATTAACAAAAGTATTGGTAGTAGCATTAGGTGTTAAAAATTATCAGCACAGCT
  TGGGACTGGCCACAAAATTCTTCTAAATCTCCCCAGGATAATCTCATGAGAGCACGGATG
  CTTTGCCCAGAATCTCTGCAACCGAGGAAGGTCTGTGGCACGGGGTGGGCCCTGAGAGAC
  TTCACCTAAAAACTTTGGGTTCATTCCCCACCCGTGTGTGTATGTAGGTGTCTCTGTAGA
  CAGTGATTAAAAATACTCCTGACT

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Temozolomide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Glioblastoma [ICD-11: 2A00.02] [1]

• Resistant Disease: Glioblastoma [ICD-11: 2A00.02]
• Resistant Drug: Temozolomide
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: STAT3/P300 axis; Regulation; N.A.
• In Vitro Model: LN229 cells; Brain; Homo sapiens (Human); CVCL_0393
• In Vitro Model: U251 cells; Brain; Homo sapiens (Human); CVCL_0021
• Experiment for Molecule Alteration: PCR; RT-qPCR; High-Throughput Sequencing; RNA Pull-Down; Western Blot; Immunofluorescence; Chromatin Immunoprecipitation; Immunohistochemistry
• Experiment for Drug Resistance: CCK-8 Assay; EdU Assay; Flow Cytometry
• Mechanism Description: Linc00942 strongly promotes SOX9 expression by interacting with TPI1 and PKM2 is found, thereby driving self-renewal and TMZ resistance in GBM cells.

References

• Ref 1: Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):133-6. doi: 10.4103/0971-5851.158852.