Molecule Information

General Information of the Molecule (ID: Mol05423)

• Name: LINC00601 ,Homo sapiens
• Molecule Type: Long non-coding RNA
• Sequence:
  GACTGCATCAAATGACCAACGGTCTGAGTATGAGGCACATCAGGGGCAGAACCAGAGAAG
  AGAAAGTACGGTGATGTGGCTGCCCAACAGGAGGTCAGCTCACCCAGACAGCTTCCTCCA
  GCTCTGAAACAGATCGACTGAGCACCAGATGAAGTTGGCATGGATGGGAGATGTGATGTA
  CAAGAGAAAAGCAAAAATTACTTGAGTTATCTCCCCGAAGTCAAAAGTAATGGGACACGC
  AGACCCTCCTGAAATTCTGAGCAGAAATTGCTGCTACATTTGAATCAGATTCTAAGAGAT
  CATCAACATTAGAAGGTGCACATCATAATTCAAATCTCTGAAGAGGAAGAAGGAAGATAT
  TGACTTCAGTCTTCATTTAGTCCTGTTATGGGACTTCCAGACACTGAAAAAACTCATCCC
  TACAGCCGGCTGGAGGATATTGTCCTGGAAGGGGCAGCTTTCACACATGGTTTGAATTCA
  ATTAGCCAGCTCCTCTGAGAGCCACTAGAGTACCATTTAGGACATTGCTTCTTGAATTCT
  CATTTGCAGCCTTGCAAATAATTTTCAAAGGTCATTAGACCATAAGGAGTTTTCATTACC
  CTTCATTCATGTCAACAGCAAACACTTACTGATTGAGCGTCCACTTGGTGCCCTATGCTA
  GGTGCTTCCAGGTGCATCCAAAAAGGGATGCAGCACAAAAAATTAAAATGACTAGAAGCA
  GCAACACATGGAAGGTAAAAATCTTTCTAATAAGAGCAATGGAAGAAACATTTCTACAAA
  TGTTAAGTTGTAAGTCAAATGTTTTTAAAAAGAAAGAAATGACAAATTTGATTAGACAAA
  AATGAGAAACTGCTTGCTGTGGTCTCAATGTGTCCCCCCAGATTCATATGTTAAACCTTA
  ATTGCCAATGTGAGAGTATTACGAGGTAGGGACTTTAGGAGGTGATTAAGTCTCTGCCTT
  CATGAATGGGATTAGTGTCCTTACAAAAGAGGTGCAAGGAAGCTGCCCATCCATTCCACC
  ACATAAGGATGCATCCAAAGGTGCCATCTGTGAAGCAGAGAATGCCCTCACTAGACATCA
  AACTAGACGTCAAACCTAAATTGGCCTTGATCTTGGGCTTCCCACCCTCCAGAACTGTGA
  GCAATAAATTTCTATTTTTTATAAATTA

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 2 drug(s) in total

Oxaliplatin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Hepatocellular carcinoma [ICD-11: 2C12.0] [1]

• Resistant Disease: Hepatocellular carcinoma [ICD-11: 2C12.0]
• Resistant Drug: Oxaliplatin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: MHCC97-H cells; Liver; Homo sapiens (Human); CVCL_4972
• In Vitro Model: Hep3B cells; Liver; Homo sapiens (Human); CVCL_0326
• Experiment for Molecule Alteration: RTFQ-PCR
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Compared with the control cells, LINC00601 expression level was significantly increased in oxaliplatin resistant cells. Both induced-oxaliplatin-resistant cells and LINC00601-overexpressed MHCC-97H cells were observed to be less sensitive to oxaliplatin administration. On the contrary, the down-regulation of LINC00601 expression in oxaliplatin resistant cells significantly increased the sensitivity to oxaliplatin treatment. Meanwhile, upregulated expression of LINC00601 inhibited the apoptosis level of HCC cell lines after oxaliplatin treatment, which was consistent with the sensitivity levels of different cell lines to oxaliplatin as above. In addition, the overexpression of LINC00601 reduced the nuclear translocation of GADD45A and the expression of GADD45A in the nucleus. Furthermore, the combination of LINC00601 and GADD45A was observed.

Temozolomide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Glioma [ICD-11: 2A00.02] [1]

• Resistant Disease: Glioma [ICD-11: 2A00.02]
• Resistant Drug: Temozolomide
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: p-STAT3 signaling pathway; Regulation; N.A.
• In Vitro Model: U251 cells; Brain; Homo sapiens (Human); CVCL_0021
• In Vitro Model: U87 cells; Brain; Homo sapiens (Human); CVCL_0022
• In Vivo Model: Nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: RT-qPCR
• Experiment for Drug Resistance: CCK8 assay; Cell migration assay; Cell invasion assay
• Mechanism Description: LINC00601, which facilitates glioma progression by modulating the p-STAT3 signaling pathway, could serve as a potential molecular target for glioma therapy.

References

• Ref 1: MicroRNA-212-3p inhibits paclitaxel resistance through regulating epithelial-mesenchymal transition, migration and invasion by targeting ZEB2 in human hepatocellular carcinoma. Oncol Lett. 2020 Oct 20(4):23