Molecule Information

General Information of the Molecule (ID: Mol05403)

• Name: IGF2-AS ,Homo sapiens
• Molecule Type: Long non-coding RNA
• Sequence:
  TCCTAGGCCCGCGGGCTAGAGGCACTTTACCGCCCGGCGGGAGCGCCTCTCCTCCGCGTC
  CCTCGCCCCAGCCCCCTGCCCGCCCCACTTTGGGACCCTCCAGCCGCTTTCCCCACAAAT
  GAGATCTTTGCAATGAGCAAACGAAAGTGGCGCGGATTTCGGGGCGCCCAGCAGGAGCGA
  GCGCAGCCGCCAGCCGCAAGTCCGCAGCCGTGTCCCGCGCCCCACGCCGGCCTCCCCGGC
  GGCAGCCGGAGACGAGCGCCAGCACCGGCGGGACAGCAGCAGATGCGGGCCGAGAGCCGG
  TCAGGGGCGCAGAGGCGGAGGGGATCGGCGCGGCGGGGAGCTCACCGCGAAGCTGGAGGC
  TGCGTCCGCGGGCGCACCAGGAGCTCAGGCAGCGAGCGATCGAACGCTCTGTGGCAGGCG
  GTGGACGCTGCTGAAGCTCTGGCTCTGAGCTCACCGCTCCGCCGTCCGTGGGACCAAGCC
  CAGCATTTTACAAACCCAGCTCCTTTCTCCAAGGGTCCTCAGAGCGCCCCTCCGTCACCC
  CCTGCAGGGCGCCGCAGACGAGGCGCTGACCTTGCGCTCACTCCCCTCGCTGGGGAAGGA
  CACACTCGCTGGCGTCAGCCCGGCCGGCCTGGGAAGTAGGACTAAGGACCCGAACTGCAA
  CCCTCCACACCAGACAGCACAGACCACCCCAAGGCTGCTCAATCTGCCCAAAGCCAAAAG
  AGCTCCCCTGCCAGGACCTCGGTGCCGTGGAGACTGCGGGGAACCTGCTCTGCCCACACC
  TGCTCTGGCCCCTAGACGGAAGCACCTGGAGCCAACCACGGAACTCCAGATCCCAGCTGT
  GTGACTGAATCCACGCCAGCCTCTCTGAGCCAAAGCTGCTTGCAGAAGGGGGAGATCCCA
  GTTCGAAGACTCCCGCGCAGAGCCTGTGGCCCTCTCTGCCAGGCCTCAGGGTGCCTGAGA
  CACTCACCTCTCTGCCTCGCAGTTGGGGCTGAGGCTGGGGCTGGCTGCCAGCCTCAGTTC
  TGGGAGCGCTGGGGTCGCCTGGGCCACAGGCCACAGCAGCTCACCTCAGGACTGGGCTCT
  CTGGCCTGCTGGGGCTCAGGCTGTGGGGCAGGCTGGGCAGGGGGCTGAGCTGGCAGCGAT
  TCAGAGCCCTGGGGCTGGGGGCTGGAATCCACCTCCTCCCACACAAGCTCGGTGGTGACT
  CTTCGGCCCCTGGGGAAAAACAAAAAGATATTGCTGAGATGACCTCTTTTAAAAGCAAAG
  CCCCCCTCCCCATACACCCCAAGCCTGAGCCCTGTCCCATCCCCCTCCCCGGGTTCCTTC
  AGGTCACCTTGTCAGGATCTGGGCAGCGGCTTCCCCCTCTAGCCCCTCCCCTGCCTAGAG
  CTCCCTCTTTCAAAGTATAAGGGAGGGAAGAAGTGGTGAGAAGTTTGCCTAGAAAGGGCT
  TCCCGGTGCTGATGGAGAGGCCGAGACCCTTCTGTTGGACAGGCTGCCCTGTTCCTGGGT
  GAGGATGGGCTTCTGCCTGGCACTGGGGGTGGAGGGTGCACACGAATGGCCCGCCTTGAG
  GGGTCATGGCACGGAATATGAAAGCCTCCTCCACCTCCAAACACCCCCACCTTGGAAGGA
  GATAAGGAGGGGGCCCCAGCAAAAGCCACTGGACACACAGCTCTGCTTGACGAGGCCAGT
  GAGGGACGGCGTGGCTGTGCTTCCTGGGGAAATGAACCCCCTCCCCACAGACACCACCCT
  GGGTGGATCGAGGAGTCTGGGTCCAGGGTGCAACAGAGAAAAACTTCATGCATGAATGAG
  CATTCCCAGGGAAACTGCCTTGGCCCCAGGGCGCCTCTCTGTGCCAGGGAGGCTGGGAGA
  GCAGCAAGGGGGACCAGGTGCGCCATCAGGAGGAGAGAAGCTAAACCTAGGGGGGACATG
  GAGGGCGGTTGTTGCCTCTCCCGGCATTTCTCCTCAGTCTCCTGTCCAATTTCTTGCTGG
  TGGTCAGGAGGCATAGGGAGGCAGGAGGGAAGGAAGCTTTACCTGTAAAATGGTGTATAT
  ATGTATAAATAAAATCTCTGCGCCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAA

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Temozolomide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Glioblastoma [ICD-11: 2A00.02] [1]

• Resistant Disease: Glioblastoma [ICD-11: 2A00.02]
• Resistant Drug: Temozolomide
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: PI3K signaling axis; Regulation; N.A.
• In Vitro Model: U87 cells; Brain; Homo sapiens (Human); CVCL_0022
• Experiment for Molecule Alteration: RT-PCR; Western blot; Immunohistochemistry
• Experiment for Drug Resistance: Cell viability assays; PI apoptosis assay
• Mechanism Description: IGF2 associated PI3K signaling shapes temozolomide sensitivity in glioblastoma

References

• Ref 1: Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab ResistanceMol Cancer Ther. 2018 Feb;17(2):521-531. doi: 10.1158/1535-7163.MCT-17-0575. Epub 2017 Nov 20.