Molecule Information

General Information of the Molecule (ID: Mol05387)

• Name: HAS2-AS1 ,Homo sapiens
• Molecule Type: Long non-coding RNA
• Sequence:
  AATTGCTCCTGAGACCCAACAGGCAGCAACGGTCCCAAGGGTGAGGGAGTGGGCAGGGAG
  AGGCTGATGGGGCTTCTACACGTTCCCTCCCGTAGCTGGGCTGCTGCAGCTCGTTCGCCC
  CAGAGGCGCGCGGTGTCCTTGAGTCCAAGTATTCAGCGCGGACGTTTGGGGGACGGAGGG
  AGAGGCGCTAGGGGAACTGGCACCTAAGACTGTGTAATAGGACACAGGTCTTGCAAGTCC
  TCCTCCCCAGGCACCGCCCCTGTGCTCCCAGCGCCTCTTTGCAGCTTTAATTATCCTTTC
  AGCGCCGTTCCCCCGCGGCTGCGTTTCCGTGGTCAGAGGAAAAAGGCTCTTTCGCCTCCC
  GGTTCTCACCCTCATACAGACCCTCCTTTCAGACCCGCCCTCCTGTTCACAGGGACCCAT
  TTCGGAGCCCTGGCTCACGCTGGGCGGGAACTGCCGTGACGAATTCCCCCCAAGGTGTTG
  ATTATCCATCCCAACCCAGCCTCTGGCTTCCCTCCCACCTCCACCCCAGCTCCCACAGGC
  CCCTCGCCCCGTTCATCGGCTGGGCGCTCGAGACGGCGCCCCCAGATCTCCCACCGGGCA
  GTGTCCCCAGCTGCAGCTGAGGAGAGAAGCGCCGGCGTGCGCGGTGCCACGTCGGAATTG
  GCTCTGGGGACGCCGCAGCTGCCGAAGCGCAGCGCGCGGTCCCCACGCACGCCCTGCCTC
  CGGGCGGCCGGCGGGCTGGCCCGGCGAGGAGAGGAGGGATGCGCGCCCTCCTCCCGCTCC
  TATCTGCGGGTGCCACCGCCTGCGTCAGGGACCCCTGGCCCGATCTTTCTGCCCCCGATA
  ACAGAAAATCTCTTTTTCGTCTTAAAAAAAAAAAAAAAAAAAAAAAAAGCCTGTGGAAGA
  CTCAGCAGAACCCAGGAAGCGCAGAATTGGGAGAAAAGTCTTTGGCTGGGGCTGTTTCAA
  GTCTCTGGTTCAATGGGCTGCTCGAAGCCAGGACTGGGTAATTCTTTCCAGACGTCTTGA
  CTTCTCCTTCCCCGCCGTTGTTGCCCTTCTGCCTCCTCCAACTTAAGGGGGTCTTAACAA
  GATCTTCTGAGGGGTGGACTTCTTTGGAACTCGACAGGACCTTGAAGACTGGGTTCTTAG
  TCCTTATCACATATATGGGCTATAATGAATAAGTCTAAACAGAAAAGTCGAATAAACTGG
  AAATGATGCTTTCATCACGTCGCACAAGGAGCTGTTTGGATCAGAAGATGACATCCTTTC
  ACCCATCCCTTTCAGGTTTTGACATCCTAAAATGTACCTTATGGAACCCATACCTGTTAT
  GTTTTCACCTGTACAAGGCAACAGAGAAAACATGGTAGTTTTTACTTGAGTAGATGTGAC
  TTAGCAATATGTTGTTGCTGACCTCCATCCCACAGCACAAAACATATGTTTATATGTCTG
  ACAGACAAAGTATCCAGAACAAGGATTTAGTACCTTCATAATCCTCTGTATATGTGGTTC
  TAGAACTTTTGGTAAAGAAACTCTTTATACTCTTATTAATTATTGAGAACCTCAAAAAAA
  GTTTATATGTTATATGTATCAATATTTACCACATTAGACATTAAAGCTGACTTAAAAAGT
  TAAAATACTTAAGTCATTTGAAGTAATAATAAATGCAGTTACATACCAACTTAATAACAT
  TTTGCGAAAATAGCTATTTTTCAAAACCTAAAGTGAGAAAAGTGGCAGTTTTCCATTTTT
  GCAAATCTCTTTGCTGTCTAGCTGATAGAAGACAGCTGGATTCTCCTATTTGCTTTTGCA
  TTCAATTGTTGTTTTGATTGAAGTATATGAAAAAAAATCTGGTGTCATACACATATATAA
  TTGGGAAATGGAAGAGTATTTACACAGGCTTTTTTAGATATTCTTCCTTTATACTACATC
  AAAACTTGATAAGTTGCAATGTTGTGAATTGGCCCAGGGCTTGGCCCTCTGAAGATTTGC
  TGAAAATCACTGACATGAAGTAGATTAATAGGATAAAAGGCATATACATTTATTTAATGT
  GTATACACAGCGGCCTTTAGAATGAAGACCCAAAGATACAGAAGAAATTGTCTGTTTTTA
  TGCTTAAGTTTAACAAAGAATGGGCAGCCGTGTAGAGATAGGATAGGACAAAAAGGGCAT
  AATCTAATGCTAGCTGACTGAGTGAGGAAGCCCAGCAAGGCCTGTCAGTGTCTCCTCAGT
  ATGAGTGAATTTTGTGTACTCTGATAATACATTAAAATCTGTTTATGTACTCTGATAACA
  CATTCAAAAAAAAAAAAAAA

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Temozolomide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Glioblastoma [ICD-11: 2A00.02] [1]

• Resistant Disease: Glioblastoma [ICD-11: 2A00.02]
• Resistant Drug: Temozolomide
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: LN-18 cells; Brain; Homo sapiens (Human); CVCL_0392
• In Vitro Model: U251 cells; Brain; Homo sapiens (Human); CVCL_0021
• In Vitro Model: LN229 cells; Brain; Homo sapiens (Human); CVCL_0393
• In Vitro Model: SNB19 cells; Brain; Homo sapiens (Human); CVCL_0535
• In Vitro Model: U87MG cells; Brain; Homo sapiens (Human); CVCL_GP63
• In Vivo Model: Nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: RT-qPCR; Western Blot; Dual-Luciferase Reporter Assays; Immunohistochemistry
• Experiment for Drug Resistance: CCK8 assay; Colony Formation Assay
• Mechanism Description: We conclude that lncRNA HAS2-AS1 promotes proliferation by functioning as a miR-137 decoy to increase LSD1 levels and thus might be a possible biomarker for GBM.

References

• Ref 1: Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):133-6. doi: 10.4103/0971-5851.158852.