Molecule Information

General Information of the Molecule (ID: Mol05355)

• Name: DRAIC ,Homo sapiens
• Molecule Type: Long non-coding RNA
• Sequence:
  CAGGGAGCTGGTTCCAGGAAAGAAGGGCACATGAGCAAACATGATGGCCCCTTTATGAGA
  GGTAATTTACTGAAATGCACAGCGATTACCTGCTCACCCAGCCCTGATGTAATTAAAAAT
  GGCAGGCTAGGGGCTCTGTTTCCCCCGGCTCTGGCAGAGAAACCTGGGTTTCGACTTGTG
  AAGCTTGAGGTTGGATGTGGGAATTGGCTTGGAGTCATAGGCGATGAGAGGGACATTAGG
  ATATTATGAAGCCCGTGAACTCAACTCCTGAGAAGGACGCAGCAGAGCGAGAGAAAAGAT
  GGAATAAAAAGGCCTACCTCATTGGGCTCGTGTGGGTGAGGAGAACTGAAGAGTCTGAGA
  GCGCGGCACGAGCCAGAGGCTACGGAAAACACTGCCCTCCTACACTCCACCTTGGAGAGA
  CCCAGAAAAGAACAAGCTTCATTTGTAAAAAAGGAAAACAACTCAGGCAATGGGGGTGGC
  TTAAAGGCACTCTACAGTGTGCAGATGCCTTCCACTTCTTCCATCTGCCCTGTCTCTCCA
  AGAACCCCTATGGCCCCGGTCTCAGAACAGAGCTGAGTGCAGAAATGAAAATCTATGGCT
  CTGTGTTCCAAAACGATGAAGAATTTCAAGATGGTGGCAGTGGTAAAATCTTTCTCCAGG
  AAAAATCTGTCCTTGGCCCAATGTGTAAACACTTGCTGAGTATTGTGAAACCAGCAACTT
  GTTCACAATTCTTCTGAATTTCTTGGGAAATTTGAAGTGGAGTACCTGTACCAACATGAA
  ATGACACGAATTTAAGTGACGCTCAACAACGAAAAGCAAAAAGAACCAAAGAGGAAGCAA
  CTGAAACAACATCTGGATGTATTTAAAAATATACAATGCCTCCAAAATCAGGTGTCATTA
  ATGAAAATTCTGAAGAAATGCCACCGGACATAGCCAACGCACCTACGCTGTTGTTATTCA
  TTTCCTGCTTTTCACAGAAAACAATTTTGTTGCATGGAAGATCGTGAACTTCAAAGGGCA
  GAGGGGAAACTGTCCCTTGGCCTCTACCCCTCCAAGGCCCCACTTTTTTGTCAACACTCC
  TTGGACGCAGCAGAAGTATGAACATAATATGGTCCTGAATGAGGCTGAGTCTTTGGGCGC
  AGAAGACCCGGGTTAATAAAAATAGGAAGGTAAGAAAAGAAAAGAAAAATCAAGACACAT
  CATAGGACTAAATTCCTATTATTTATCCACTCAGGATTGACCACCCCTTTGGGCCAGATA
  GTTGTACCCCCATGTACCAGGTGGGCACATGAAGACACAAGAAGTGCTGTGATGGTTCAT
  TTTGCACGTCACCTTGCGTGGAGTATGCCAACTCATTGTTTGGTCAAACACTAGTCTGGA
  CATGGTGGTAAAGGTATTTTTTAGATGAGATTAACACTTAAATCAGTAAAGCAGGTTACC
  CACCATACTACGGGTGGGCCCTGTCCAATCAGTTGAAGGCATTAAGAACAAAGATTGAGG
  TTTCCTAAAGAAGATGGAATTCTCCTTGAGACTACAACATAGAAACCCTATCTGAGTTTC
  CAGCCTGTTGCCCTGTGGAATTCAAACTCAGGACTCCGGTCTATGACATTAACCCTCACT
  TAACTTTTCAGCCTGCCAGCCTGCCCTATGGATTTCGGACTTGCCAGCCACACAATTCCT
  TAAAATAAATCTCTCCGTCTCTGTC

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Temozolomide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Brain glioma [ICD-11: 2A00.02] [1]

• Resistant Disease: Brain glioma [ICD-11: 2A00.02]
• Resistant Drug: Temozolomide
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Autophagy; Regulation; N.A.
• In Vitro Model: A172 cells; Brain; Homo sapiens (Human); CVCL_0131
• In Vitro Model: U87 cells; Brain; Homo sapiens (Human); CVCL_0022
• Experiment for Molecule Alteration: RT-qPCR
• Mechanism Description: DRAIC activates AMP-activated protein kinase (AMPK) by downregulating the NF-kappaB target gene GLUT1, and thus represses mTOR, leading to downstream effects, such as a decrease in protein translation and increase in autophagy. DRAIC, therefore, has an effect on multiple signal transduction pathways that are important for oncogenesis, namely, the NF-kappaB pathway and AMPK-mTOR-S6K/ULK1 pathway. The regulation of NF-kappaB, protein translation and autophagy by the same lncRNA explains the tumor-suppressive role of DRAIC in different cancers and reinforces the importance of lncRNAs as emerging regulators of signal transduction pathways.

References

• Ref 1: Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):133-6. doi: 10.4103/0971-5851.158852.