Molecule Information

General Information of the Molecule (ID: Mol05352)

• Name: DLX6-AS1 ,Homo sapiens
• Molecule Type: Long non-coding RNA
• Sequence:
  ATTTCACACCTGGATGTGCTCACTCAACCAAGAATATAGAGAAAGAGCTTCTGCCCTGAG
  ACTCAGAAAAATATTCTCCTGTGCTTTGGTTCAGTATAGATTTCTAAACCCTGATCATTG
  CTTAAGAGATATTCACTGAGGACAGAGTCTTGCTCTATTGCCCAGGCTGCAACTGGTGTG
  ATCTCGGCTCACTACAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAAGCTCC
  CAAGTAGCTGGGATTACAAGCATGCACCACCATGCCTGGCTAATTTTTGTATTTTTAGTG
  GAGACGGGGTTTCGCCACATTGGCCAGGGTGGTCTTGAACTCCTGACCTCAAGTGATCCA
  CCTGCCTTGGCCTCCCAAAGTGCTGGGATTATAAGCATGAGCCACTGCACCCAGCCTTAT
  ACTGAACTTTCAATGGGTTCAATTCCACTAGGAGCATAAAGGCCACTGCATATGAGTTGT
  GGAAAGAAGAGATTAGAAGAAGGAAGAACTTGAGATGAGTTCCTCCCTTCAACATTCTGT
  CTCCTCCTACCTAGCATCTTCTTTCTTTTAGTCTTTCTAGAATGTCCATCTGTTTTTGGC
  CATTGCGGAGAGAGAAGCTGAGCTTTAAAGGAGTAGGAGCTTCAAAGGCGTAGGAGCTTC
  AAAATTCTTGTTTCTTCATGTTTGATCACCCTTCTAAACCTGTCTTCTGTTCCTTCTGCT
  ATTCTTTTTTCTTAGAGCATAGGAAAGGGGAGCTTTTAAATTAATACTTAAAGCATGGAA
  AAAAAGAACTTGAGAAGAAAGTAAAACAAGGGAGATGAGGCTAGTAAAGTAAGGAAAATG
  AAGAGGAAGAGGAGGAAGGGTTAGCTTCTAAATTCCAAGTCAAATTGATATGGAACAGGC
  AAGCCGCTTGTCTTACTTAAACTTCAGAAAAGGATCTGCTGAAACTTGATAGAAATGGAA
  AGGGAAATCCTTGGGGTGGGGAACCTCCAAACATTAGTAATGATATTGAACAACTCAAAG
  TATTGAGGAAATCTGCAGGCTACATGCCTGAAGATTACCCATGCAGATAGACCAAAAGGA
  TTAGAATTATCTGTTGATATTAGTAATATTTATTGACATCTAGCTAGTATTGGTAATTTT
  AAGTTTTAGATTAATTTCTTTGGTAATAGCTATGATATATTTTATAGACAAGAATTATAT
  CTATAGGCTTGCTATCATAGGCTCTTTTAATCAGCATTAATTTAGTCTACTGATTTTTAG
  CACATTTGAATCATTCACTTATGCTAGGTAACTCATTGCAAAATAAAAAGATGATTCCTG
  TATGTATGGCAGCTATACATTAAGGAGGAGTCTACCAGAATATGAAAAAGTCAGCTGACC
  TAAATATTGCTGAGACAAAGGAAAACCCACTCCCTTGGAGGAGCATGACCTTTTCCTGTA
  ATTCTTCCCACTGCTGTTGTTGAGCTCCTTGGATCCTGGCTCCTGGACACCATCATCAAG
  AAGACTTTATGGATGGGCTGTCCACCCACTGAGAGAAGAGGAGCATCAGCTACAGTTTCT
  CTCTAGATTGCCTTCTTCATTTTGAGTAATGACTGTCAGCAGGGTCAGATTAAACACAAA
  ACAACTGGACAATTGCTTGGAGGACTAAACTATAAGGGCACTAACATGTCAATAGTAGGC
  TAACACATCCATGGAAAATATATTTACCAGCTCTTCTCTCAGGGAGGATTCTGTGTGGGG
  TTGGAAGTAATGATTTGTTAAATTCCTTAGGGGTAGAAAGTAGGGCATAATCAGAATATA
  GAGGAATATGCTGTTTGACTTCAGGGTTTCTGTTTTTCTTACTAGGATATATAAAACAGG
  GACTCTAGCTAGATTGTTTATGACCACAGAGGGTAGGCTGAGTGCTCCCATGATCTTCCT
  GCTTGGTTCTTGCCCATACAGAGGTCAGCCTTTCCTCTAATAAAGATTGAACAAGTAGTG
  GTCTGAGGGA

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Temozolomide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Glioblastoma [ICD-11: 2A00.02] [1]

• Resistant Disease: Glioblastoma [ICD-11: 2A00.02]
• Resistant Drug: Temozolomide
• Molecule Alteration: Expression; Up-regulation
• Mechanism Description: Li et al. found that DLX6-AS1 expression was dramatically upregulated in glioma cells and tissues. Additionally, DLX6-AS1 overexpression was associated with a poorer prognosis for glioma patients, according to the clinical correlation.

References

• Ref 1: MicroRNA-212-3p inhibits paclitaxel resistance through regulating epithelial-mesenchymal transition, migration and invasion by targeting ZEB2 in human hepatocellular carcinoma. Oncol Lett. 2020 Oct 20(4):23