Molecule Information

General Information of the Molecule (ID: Mol05351)

Name	DLGAP1-AS1 ,Homo sapiens
Molecule Type	Long non-coding RNA
Sequence	AGCAGCTGCCCCTGCAAATGTCAGCGCCAGCCCAGTCAAAAGAGCTTGAAACCTACCAAG CCGGAGGACTGTGCTGTGCCTCTCTCGCCCACATTTTCCCCAAGCACTCTCAGGAACCTG GCAACAGTGTCCCCTTGTGGCCAAGCCTGGAACATCACATCTGTACGTTGCAATCTGTGG ATCAGCTACGAGACTGAGAGAAAGGAATGAAAGGATGGAAGAATTACAAGATCAGGCACT GCTGTCTGTCTGTTCCACGGATGTAACCACAGCACACGCGTGGCTCACGGTACTAGTGTG ATAAATGCTTGTTACATGAAGGCGTGAACAGGGATGAGAAGAGACTTCCTGGAGAAACAA AAGGACTAACAATCAGGAAGGGGAGGTGATCGGGGCAGGAGTAAAGTGGACACCTCAGCA AAGCCATTCGCTGTGATCTCTGATTGTGCAGTGTCATGTCCTGTCACCAGAGCCCCCTCG TGTTTGATGTTGGCCAATGCCGCCAGCATGATCTAGCAGGCCAAATCCTAATCTACCATT CTCTGACACCAGCTGGTCCCCTGGGTCGTCCACCCGATGTCCCCCATTCTCCCCACTTGG CCTCCCCCACAGGCTCTCGGCAAAGGACCGTGGGAGGCACCTGTGACACTGCCCTTTTCC TGTGCAGCTGTTTTTCTTCTTCATTCTTTTCACTCCTCGTTACTCTTTTTTTTTTCACTC TCAGCCCACACAAAACTAGGAACTTTGTTATTCTACTTATTTTTCTGTACTCTGTCTGTT TGCACACAGATGGATATCTGAGAGCCAGCGAACTTTCTTTACCTCCTAGTATCATTTCAT GAAAATTAGTAGCACCTGCACAATGGGGCCTTGGAGACAGGAATAAAAGGAAAAATCTGG AATGGAATCACATGACGCAACAGGCTATGAAGACTCCCTGCCCGGCTGCTATATGTCTGG TAAACAGAATAAATAGTACTTGAGCATCCCTGAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAA Click to Show/Hide
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Temozolomide

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Glioblastoma [ICD-11: 2A00.02]				[1]
Resistant Disease	Glioblastoma [ICD-11: 2A00.02]			Disease Info
Resistant Drug	Temozolomide			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	U87MG cells	Brain	Homo sapiens (Human)	CVCL_GP63
	U251 cells	Brain	Homo sapiens (Human)	CVCL_0021
	HEK 293 cells	Kidney	Homo sapiens (Human)	CVCL_0045
Experiment for Molecule Alteration	RT-qPCR
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Our conclusion suggested that DLGAP1-AS1 may be a potential prognosis biomarker and facilitated the occurrence and development of glioma via ATG4A in GBM.

References

Ref 1	Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):133-6. doi: 10.4103/0971-5851.158852.