Molecule Information

General Information of the Molecule (ID: Mol04453)

Name	hsa-miR-770-5p ,Homo sapiens
Synonyms	hsa-miR-770-5p Click to Show/Hide
Molecule Type	Mature miRNA
Mature Accession	MIMAT0003948
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Trastuzumab

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Breast adenocarcinoma [ICD-11: 2C60.1]				[1]
Sensitive Disease	Breast adenocarcinoma [ICD-11: 2C60.1]			Disease Info
Sensitive Drug	Trastuzumab			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	EGFR/HER2/IGF1R signaling pathway		Regulation	N.A.
In Vitro Model	BT-474 cells	Breast	Homo sapiens (Human)	CVCL_0179
	SK-BR-3 cells	Pleural effusion	Homo sapiens (Human)	CVCL_0033
Experiment for Molecule Alteration	Western blot assay
Experiment for Drug Resistance	Cell proliferation assay
Mechanism Description	The effect of miR-770-5p on the EGFR/HER2/IGF1R crosstalk signaling. In general, tumorigenesis of breast cancer is assumed to be associated with the PI3K and MAPK pathways and signaling these pathway complex has critical roles in cell proliferation in HER2 amplified cells. Trastuzumab can block this signaling, either by inhibiting the activity of EGFR and HER2 kinases directly or through HER2 binding at the cell surface. miR-770-5p can reduce dissociation of receptor crosstalk signaling, which increases its activity.

References

Ref 1	miR-770-5p-induced cellular switch to sensitize trastuzumab resistant breast cancer cells targeting HER2/EGFR/IGF1R bidirectional crosstalk. Turk J Biol. 2024 Feb 5;48(2):153-162.