Molecule Information

General Information of the Molecule (ID: Mol04445)

• Name: Hypoxia up-regulated protein 1 (HYOU1) ,Homo sapiens
• Synonyms: 150 kDa oxygen-regulated protein; 170 kDa glucose-regulated protein; Heat shock protein family H member 4
• Molecule Type: Protein
• Gene Name: HYOU1
• Gene ID: 10525
• Sequence:
  MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVL
  NKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQAR
  F PEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPV
  FF NQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGS
  TVC TIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRA
  KDVR ENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADL
  FERVP GPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEA
  AAMGAV YQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRM
  GPYPQRK VITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYP
  DYESKGIK AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTP
  DAKENGTDT VQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGE
  KATEKENGDK SEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLP
  DLPEDKLAQSV QKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQR
  EEISGKLSAAST WLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDN
  LLNHSSMFLKGAR LIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVL
  LSKDIEAKMMALDR EVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPA
  GQTEDAEPISEPEKV ETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL
• Function: Has a pivotal role in cytoprotective cellular mechanismstriggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATPnucleotide exchange and thereby activates the unfolded protein response pathway in the presence of endoplasmic reticulum stress . May play a role as a molecular chaperone and participatein protein folding. {ECO:0000250|UniProtKB:Q9JKR6,ECO:0000269|PubMed:10037731}.
• Uniprot ID: HYOU1_HUMAN
• Ensembl ID: ENSG0000014942821
• HGNC ID: HGNC:16931

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Cisplatin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Cervical cancer [ICD-11: 2C77.0] [1]

• Resistant Disease: Cervical cancer [ICD-11: 2C77.0]
• Resistant Drug: Cisplatin
• Molecule Alteration: Expression; Up-regulation
• Cell Pathway Regulation: Retrograde endocannabinoid signaling pathway; Inhibition; hsa04723
• Experiment for Molecule Alteration: Western blot assay

Disease Class: Cervical cancer [ICD-11: 2C77.0] [1]

• Resistant Disease: Cervical cancer [ICD-11: 2C77.0]
• Resistant Drug: Cisplatin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Retrograde endocannabinoid signaling pathway; Inhibition; hsa04723
• In Vitro Model: Hela cells; Cervix uteri; Homo sapiens (Human); CVCL_0030
• In Vitro Model: HeLa/DDP cells; Uterus; Homo sapiens (Human); CVCL_C869
• Experiment for Molecule Alteration: Western blot assay
• Experiment for Drug Resistance: CCK8 assay

Disease Class: Cervical cancer [ICD-11: 2C77.0] [1]

• Resistant Disease: Cervical cancer [ICD-11: 2C77.0]
• Resistant Drug: Cisplatin
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Retrograde endocannabinoid signaling pathway; Inhibition; hsa04723
• In Vitro Model: HeLa/DDP cells; Uterus; Homo sapiens (Human); CVCL_C869
• Experiment for Molecule Alteration: Western blot assay
• Experiment for Drug Resistance: Western blot assay

Disease Class: Cervical cancer [ICD-11: 2C77.0] [1]

• Resistant Disease: Cervical cancer [ICD-11: 2C77.0]
• Resistant Drug: Cisplatin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Retrograde endocannabinoid signaling pathway; Inhibition; hsa04723
• In Vitro Model: Hela cells; Cervix uteri; Homo sapiens (Human); CVCL_0030
• Experiment for Molecule Alteration: Western blot assay
• Experiment for Drug Resistance: Western blot assay

References

• Ref 1: Overexpression of HYOU1 is associated with cisplatin resistance and may depend on m(6)A modification in patients with cervical cancer. Oncol Lett. 2024 Nov 26;29(2):77.