Molecule Information

General Information of the Molecule (ID: Mol04430)

Name	Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) ,Homo sapiens
Synonyms	Solute carrier family 30 member 3 ; Zinc transporter 3 Click to Show/Hide
Molecule Type	Protein
Gene Name	SLC30A3
Gene ID	7781
Sequence	MEPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPL PPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGS L FSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGG AM LLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFV HVL GDLLQSFGVLAASILIYFKPQYKAADPISTFLFSICALGSTAPTLRDVLRILMEGT PRNV GFEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSR LYSRF GFSSCTLQVEQYQPEMAQCLRCQEPPQA Click to Show/Hide
Function	Probable proton-coupled zinc ion antiporter mediating theimport of zinc from cytoplasm into synaptic vesicles and participatingto cellular zinc ion homeostasis in the brain.{ECO:0000269\|PubMed:17349999, ECO:0000269\|PubMed:19521526,ECO:0000269\|PubMed:26647834}. Click to Show/Hide
Uniprot ID	ZNT3_HUMAN
Ensembl ID	ENSG0000011519411
HGNC ID	HGNC:11014
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cisplatin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: cancer [ICD-11: 2D4Z]				[1]
Sensitive Disease	cancer [ICD-11: 2D4Z]			Disease Info
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HCT15 cells	Colon	Homo sapiens (Human)	CVCL_0292
	HuTu80 cells	Small intestine	Homo sapiens (Human)	CVCL_1301
Experiment for Drug Resistance	MTT assay
Mechanism Description	The cell growth rate, mitochondrial activity, zinc accumulation, and sensitivity to the drugs cetuximab and cisplatin were investigated in functional tests. Overexpression or depletion of SLC30A or SLC39A family genes resulted in the deep reshaping of intracellular signaling and provoked hyperactivation of mitochondrial respiration. Variation in the expression of the SLC30A/SLC39A genes did not increase the sensitivity to cetuximab but significantly altered the sensitivity to cisplatin: overexpression of?SLC30A10?resulted in an ~2.7-4 times increased IC50 of cisplatin, and overexpression of?SLC30A3?resulted in an ~3.3 times decreased IC50 of cisplatin. The SLC30A/SLC39A genes should be considered as potential cancer drug resistance biomarkers and putative therapeutic targets.

References

Ref 1	Forced Overexpression and Knockout Analysis of SLC30A and SLC39A Family Genes Suggests Their Involvement in Establishing Resistance to Cisplatin in Human Cancer Cells. Int J Mol Sci. 2024 Nov 9;25(22):12049.