Molecule Information

General Information of the Molecule (ID: Mol04399)

• Name: Baculoviral IAP repeat-containing protein 3 (BIRC3) ,Homo sapiens
• Synonyms: Apoptosis inhibitor 2; Cellular inhibitor of apoptosis 2; IAP homolog C; Inhibitor of apoptosis protein 1; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3 ; TNFR2-TRAF-signaling complex protein 1
• Molecule Type: Protein
• Gene Name: BIRC3
• Gene ID: 330
• Sequence:
  MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGV
  NDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTN
  S THSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQT
  WP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIEN
  QLQ DTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCD
  GGLR CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDE
  NAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVN
  DLVLDL LNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGI
  INEQEHD VIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIK
  YIPTEDVS DLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPIC
  RSTIKGTVR TFLS
• Function: Multi-functional protein which regulates not only caspasesand apoptosis, but also modulates inflammatory signaling and immunity,mitogenic kinase signaling and cell proliferation, as well as cellinvasion and metastasis. Acts as an E3 ubiquitin-protein ligaseregulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: actsas a positive regulator of the canonical pathway and suppressesconstitutive activation of non-canonical NF-kappa-B signaling. Thetarget proteins for its E3 ubiquitin-protein ligase activity include:RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, andBCL10. Acts as an important regulator of innate immune signaling viaregulation of Toll-like receptors , Nodlike receptors andRIG-I like receptors , collectively referred to as patternrecognition receptors . Protects cells from spontaneous formationof the ripoptosome, a large multi-protein complex that has thecapability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinatingRIPK1 and CASP8. {ECO:0000269|PubMed:21931591,ECO:0000269|PubMed:23453969}.
• Uniprot ID: BIRC3_HUMAN
• Ensembl ID: ENSG0000002344517
• HGNC ID: HGNC:591

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Arsenic trioxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Acute promyelocytic leukemia [ICD-11: 2A60.2] [1]

• Resistant Disease: Acute promyelocytic leukemia [ICD-11: 2A60.2]
• Resistant Drug: Arsenic trioxide
• Molecule Alteration: Expression; Amplification
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: NB4 cells; Bone marrow; Homo sapiens (Human); CVCL_0005
• Experiment for Molecule Alteration: RT-PCR
• Experiment for Drug Resistance: MTS assay
• Mechanism Description: ATO-resistant APL cells showed upregulation of?APAF1,?BCL2,?BIRC3, and?NOL3?genes, while?CD70?and?IL10?genes were downregulated, compared to ATO-sensitive cells.

References

• Ref 1: Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors. Pharmaceuticals (Basel). 2024 Nov 14;17(11):1529.