Molecule Information

General Information of the Molecule (ID: Mol04394)

• Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (PLCB3) ,Homo sapiens
• Synonyms: Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3
• Molecule Type: Protein
• Gene Name: PLCB3
• Gene ID: 5331
• Sequence:
  MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME
  VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLN
  F MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKM
  FS ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKG
  KPY LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGF
  SRYL GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALL
  WGCRC VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFEN
  HVDSAK QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRP
  SAGGPDS AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSL
  EPQKSLGD EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMS
  TLVNYIEPV KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPK
  GTRVDSSNYM PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPD
  KSFDPFTEVIV DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQ
  GNSFNPVWDEEP FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRN
  EANQPLCLPALLI YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQ
  AGQETCQDTQSQQL GSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASI
  LSEVAPTPLDELRGH KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGR
  CRLRPGALGGAADVED TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQ
  ALQRLREVVLDANTTQF KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELT
  EINRRHITESVNSIRRLE EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRA
  RLPQEIRRSLLGEMPEGLG DGPLVACASNGHAPGSSGHLSGADSESQEENTQL
• Function: Catalyzes the production of the second messenger moleculesdiacylglycerol and inositol 1,4,5-trisphosphate .Key transducer of G protein-coupled receptor signaling: activated byG/G G alpha proteins downstream of G protein-coupled receptorsactivation . In neutrophils,participates in a phospholipase C-activating N-formyl peptide-activatedGPCR signaling pathway by promotingRASGRP4 activation by DAG, to promote neutrophil functional responses. {ECO:0000250|UniProtKB:P51432,ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926,ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}.
• Uniprot ID: PLCB3_HUMAN
• Ensembl ID: ENSG0000014978213
• HGNC ID: HGNC:9056

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Cabazitaxel

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Prostate cancer [ICD-11: 2C82.0] [1]

• Resistant Disease: Prostate cancer [ICD-11: 2C82.0]
• Resistant Drug: Cabazitaxel
• Molecule Alteration: Phosphorylation; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Oxytocin signaling pathway; Activation; hsa04921
• In Vitro Model: DU145CR cells; prostate; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: MS analysis
• Mechanism Description: Pathway analysis revealed that clusters in two cases showed up-regulation of the oxytocin (OXT) receptor-signaling pathway. Spatial gene expression analysis of CBZ-resistant prostate cancer tissues confirmed the heterogeneous expression of OXT-signaling molecules. We identified the OXT-signaling pathway as a potential target for CBZ-resistant CRPC using single-cell transcriptomic analysis of CTCs. CLO may potentially overcome CBZ resistance in CRPC by inhibiting the OXT-signaling pathway.

References

• Ref 1: G-protein signaling of oxytocin receptor as a potential target for cabazitaxel-resistant prostate cancer. PNAS Nexus. 2024 Jan 4;3(1):pgae002.