Molecule Information

General Information of the Molecule (ID: Mol04359)

Name	CD70 antigen (CD70) ,Homo sapiens
Synonyms	CD27 ligand ; Tumor necrosis factor ligand superfamily member 7 ; CD_antigen=CD70 Click to Show/Hide
Molecule Type	Protein
Gene Name	CD70
Gene ID	970
Sequence	MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAEL QLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTT A SRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPS RN TDETFFGVQWVRP Click to Show/Hide
Function	Expressed at the plasma membrane of B cells, it is the ligandof the CD27 receptor which is specifically expressed at the surface ofT cells . The CD70-CD27 signaling pathway mediates antigen-specific T cell activation andexpansion which in turn provides immune surveillance of B cells. {ECO:0000269\|PubMed:28011863,ECO:0000269\|PubMed:28011864, ECO:0000269\|PubMed:8387892}. Click to Show/Hide
Uniprot ID	CD70_HUMAN
Ensembl ID	ENSG0000012572611
HGNC ID	HGNC:11937
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Arsenic trioxide

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Acute promyelocytic leukemia [ICD-11: 2A60.2]				[1]
Resistant Disease	Acute promyelocytic leukemia [ICD-11: 2A60.2]			Disease Info
Resistant Drug	Arsenic trioxide			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	NB4 cells	Bone marrow	Homo sapiens (Human)	CVCL_0005
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	MTS assay
Mechanism Description	ATO-resistant APL cells showed upregulation of?APAF1,?BCL2,?BIRC3, and?NOL3?genes, while?CD70?and?IL10?genes were downregulated, compared to ATO-sensitive cells.

References

Ref 1	Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors. Pharmaceuticals (Basel). 2024 Nov 14;17(11):1529.