Molecule Information

General Information of the Molecule (ID: Mol04319)

Name	Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) ,Homo sapiens
Synonyms	Adenylate cyclase-inhibiting G alpha protein Click to Show/Hide
Molecule Type	Protein
Gene Name	GNAI2
Gene ID	2771
Sequence	MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG YSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGV L PDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRT RV KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAE DEE MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANK YDEA ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF Click to Show/Hide
Function	Guanine nucleotide-binding proteins are involvedas modulators or transducers in various transmembrane signalingsystems. The G proteins are involved in hormonal regulation ofadenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.{ECO:0000269\|PubMed:17635935}.; [Isoform sGi2]: Regulates the cell surface density ofdopamine receptors DRD2 by sequestrating them as an intracellular pool.{ECO:0000269\|PubMed:17550964}. Click to Show/Hide
Uniprot ID	GNAI2_HUMAN
Ensembl ID	ENSG0000011435317
HGNC ID	HGNC:4385
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cabazitaxel

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Prostate cancer [ICD-11: 2C82.0]				[1]
Resistant Disease	Prostate cancer [ICD-11: 2C82.0]			Disease Info
Resistant Drug	Cabazitaxel			Drug Info
Molecule Alteration	Phosphorylation		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Oxytocin signaling pathway		Activation	hsa04921
In Vitro Model	DU145CR cells	prostate	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	MS analysis
Mechanism Description	Pathway analysis revealed that clusters in two cases showed up-regulation of the oxytocin (OXT) receptor-signaling pathway. Spatial gene expression analysis of CBZ-resistant prostate cancer tissues confirmed the heterogeneous expression of OXT-signaling molecules. We identified the OXT-signaling pathway as a potential target for CBZ-resistant CRPC using single-cell transcriptomic analysis of CTCs. CLO may potentially overcome CBZ resistance in CRPC by inhibiting the OXT-signaling pathway.

References

Ref 1	G-protein signaling of oxytocin receptor as a potential target for cabazitaxel-resistant prostate cancer. PNAS Nexus. 2024 Jan 4;3(1):pgae002.