Molecule Information

General Information of the Molecule (ID: Mol04314)

Name	DNA nucleotidylexotransferase (DNTT) ,Homo sapiens
Synonyms	Terminal addition enzyme; Terminal deoxynucleotidyltransferase Click to Show/Hide
Molecule Type	Protein
Gene Name	DNTT
Gene ID	1791
Sequence	MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKG FRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEM T GKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAEN CE FRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEV KAV LNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYY EDLV SCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTE DEEQL LQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRV DSDQSS WQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDN HALYDKT KRIFLKAESEEEIFAHLGLDYIEPWERNA Click to Show/Hide
Function	Template-independent DNA polymerase which catalyzes therandom addition of deoxynucleoside 5'-triphosphate to the 3'-end of aDNA initiator. One of the in vivo functions of this enzyme is theaddition of nucleotides at the junction of rearranged Igheavy chain and T-cell receptor gene segments during the maturation ofB- and T-cells. {ECO:0000250\|UniProtKB:P09838}. Click to Show/Hide
Uniprot ID	TDT_HUMAN
Ensembl ID	ENSG000001074478
HGNC ID	HGNC:2983
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Inotuzumab ozogamicin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Disease Class: Mature B-cell neoplasms [.]				[1]
Resistant Disease	Mature B-cell neoplasms [.]			Disease Info
Resistant Drug	Inotuzumab ozogamicin			Drug Info
Molecule Alteration	Missense mutation		p.R183W
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	pre-InO and/or post-InO tumor cells	N.A.	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	GeneSeq assay; Mutation assay
Mechanism Description	Multiple mechanisms drive CD22 antigen escape, including epitope loss (protein truncation and destabilization) and epitope alteration.Hypermutation caused by error-prone DNA damage repair may serve as a driver of CD22 mutation and escape.

References

Ref 1	Genomic determinants of response and resistance to inotuzumab ozogamicin in B-cell ALL. Blood. 2024 Jul 4;144(1):61-73.