Molecule Information

General Information of the Molecule (ID: Mol04310)

Name	Ferritin heavy chain (FTH1) ,Homo sapiens
Synonyms	Cell proliferation-inducing gene 15 protein Click to Show/Hide
Molecule Type	Protein
Gene Name	FTH1
Gene ID	2495
Sequence	MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQS HEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELH K LATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGD SD NES Click to Show/Hide
Function	Stores iron in a soluble, non-toxic, readily available form.Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited asferric hydroxides after oxidation . Also plays a rolein delivery of iron to cells . Mediates iron uptake incapsule cells of the developing kidney . Delivery tolysosomes is mediated by the cargo receptor NCOA4 for autophagicdegradation and release of iron .{ECO:0000250\|UniProtKB:P09528, ECO:0000269\|PubMed:24695223,ECO:0000269\|PubMed:26436293, ECO:0000269\|PubMed:9003196}. Click to Show/Hide
Uniprot ID	FRIH_HUMAN
Ensembl ID	ENSG0000016799616
HGNC ID	HGNC:3976
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Alectinib

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Lung adenocarcinoma [ICD-11: 2C25.0]				[1]
Resistant Disease	Lung adenocarcinoma [ICD-11: 2C25.0]			Disease Info
Resistant Drug	Alectinib			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	ALK1903 cells	N.A.	Homo sapiens (Human)	N.A.
	DTP cells	N.A.	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	Western blot assay
Experiment for Drug Resistance	CellTiter-Glo 3D cell viability assay
Mechanism Description	DTP cells evade ALK-TKI-induced ROS-mediated cell death through GPX4 activity. From these data showing elevated levels of ROS that arise through decreased levels of various antioxidant factors and decreased GSH synthesis, it might be expected that ROS-mediated cell death should occur in alectinib-induced DTP cells. However, DTP cells concurrently upregulated GPX4 protein, suggesting that ALK1903 DTP cells are able to evade ROS-mediated cell death by reducing ROS level in a GPX4-dependent manner.

References

Ref 1	Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK-inhibitor-induced tolerant persister cells in ALK-fusion-positive lung cancer. Mol Oncol. 2025 Feb;19(2):519-539.