Molecule Information

General Information of the Molecule (ID: Mol04300)

• Name: Hyaluronan mediated motility receptor (HMMR) ,Homo sapiens
• Synonyms: Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD_antigen=CD168
• Molecule Type: Protein
• Gene Name: HMMR
• Gene ID: 3161
• Sequence:
  MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
  TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL
  N AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE
  TK MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYI
  EEI SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLL
  EKEK EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSS
  LHQKL CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELK
  LLEEKL KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDL
  KLENSSL QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVS
  FLQKITDL QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK
  PFQLQLDAF EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ
  LKSEVSKLRC QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGN
  TNCYRAPMECQ ESWK
• Function: Receptor for hyaluronic acid . Involvedin cell motility . When hyaluronan binds to HMMR, thephosphorylation of a number of proteins, including PTK2/FAK1 occurs.May also be involved in cellular transformation and metastasisformation, and in regulating extracellular-regulated kinase activity. May act as a regulator of adipogenisis .{ECO:0000250|UniProtKB:Q00547}.
• Uniprot ID: HMMR_HUMAN
• Ensembl ID: ENSG0000007257120
• HGNC ID: HGNC:5012

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Epirubicin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Breast adenocarcinoma [ICD-11: 2C60.1] [1]

• Resistant Disease: Breast adenocarcinoma [ICD-11: 2C60.1]
• Resistant Drug: Epirubicin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: RHAMM signaling pathway; Regulation; N.A.
• In Vitro Model: 231-EPIR cells; Breast; Homo sapiens (Human); N.A.
• In Vitro Model: M-EPIR cells; Breast; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: RT-PCR
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: We demonstrated that RHAMM immensely contributes to breast cancer chemoresistance by several mechanisms: promoting proliferation and migration, enrichment of breast cancer stemness, and induction of EMT. Also, we found that RHAMM served as a potent prognostic factor in breast cancer patients, especially in those who received chemotherapy.

References

• Ref 1: Receptor for Hyaluronan Mediated Motility (RHAMM)/Hyaluronan Axis in Breast Cancer Chemoresistance. Cancers (Basel). 2024 Oct 25;16(21):3600.