Molecule Information

General Information of the Molecule (ID: Mol04299)

• Name: Hyaluronan mediated motility receptor (HMMR) ,Homo sapiens
• Synonyms: Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD_antigen=CD168
• Molecule Type: Protein
• Gene Name: HMMR
• Gene ID: 3161
• Sequence:
  MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
  TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL
  N AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE
  TK MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYI
  EEI SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLL
  EKEK EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSS
  LHQKL CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELK
  LLEEKL KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDL
  KLENSSL QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVS
  FLQKITDL QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK
  PFQLQLDAF EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ
  LKSEVSKLRC QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGN
  TNCYRAPMECQ ESWK
• Function: Receptor for hyaluronic acid . Involvedin cell motility . When hyaluronan binds to HMMR, thephosphorylation of a number of proteins, including PTK2/FAK1 occurs.May also be involved in cellular transformation and metastasisformation, and in regulating extracellular-regulated kinase activity. May act as a regulator of adipogenisis .{ECO:0000250|UniProtKB:Q00547}.
• Uniprot ID: HMMR_HUMAN
• Ensembl ID: ENSG0000007257120
• HGNC ID: HGNC:5012

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Enzalutamide

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Prostate cancer [ICD-11: 2C82.0] [1]

• Sensitive Disease: Prostate cancer [ICD-11: 2C82.0]
• Sensitive Drug: Enzalutamide
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• Cell Pathway Regulation: Downstream AR signaling pathway; Regulation; N.A.
• Experiment for Molecule Alteration: Western blot assay; qRT-PCR
• Experiment for Drug Resistance: Cell viability assay; Apoptosis assay
• Mechanism Description: Transient downregulation of HMMR using SMARTpool siRNA (siHMMR) markedly inhibited cell proliferation and induced apoptosis compared to control siRNA (siCON) in enzalutamide-sensitive LNCaP and enzalutamide-resistant MR49F cells. Additionally, siHMMR suppressed the colony-forming abilities of both LNCaP and MR49F cells, indicative of reduced survival ability.

References

• Ref 1: Targeting hyaluronan-mediated motility receptor (HMMR) enhances response to androgen receptor signalling inhibitors in prostate cancer. Br J Cancer. 2023 Oct;129(8):1350-1361.