Molecule Information

General Information of the Molecule (ID: Mol04282)

• Name: DNA-directed RNA polymerase beta-subunit (rpoB) ,Mycobacterium tuberculosis
• Synonyms: DNA-directed RNA polymerase beta-subunit (rpoB)
• Molecule Type: Protein

Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Rifampin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Tuberculosis [ICD-11: 1B10.0] [1]

• Resistant Disease: Tuberculosis [ICD-11: 1B10.0]
• Resistant Drug: Rifampin
• Molecule Alteration: Mutations; Q24K+L28M+R30E+A92K
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: THP-1 cells; monocytic; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: Microarray assay
• Experiment for Drug Resistance: Functional enrichment assay
• Mechanism Description: The overexpression of many interferon-stimulated genes (ISGs) in cells infected with the isoniazid-resistant strain, compared to the rifampin-resistant and the drug-sensitive strains.

References

• Ref 1: Differential Host Gene Expression in Response to Infection by Different Mycobacterium tuberculosis Strains-A Pilot Study. Microorganisms. 2024 Oct 25;12(11):2146.