Molecule Information

General Information of the Molecule (ID: Mol04250)

• Name: Erad and inmad ubiquitin-conjugating enzymes (E2s) ,Homo sapiens
• Synonyms: Erad and inmad ubiquitin-conjugating enzymes (E2s)
• Molecule Type: Protein

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hygromycin B

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Sensitive Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Sensitive Drug: Hygromycin B
• Molecule Alteration: Missense mutation; Rv2043c; p.His57Asp
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Yeast strains; 4751
• Experiment for Molecule Alteration: PCR
• Experiment for Drug Resistance: Cell growth rate assay
• Mechanism Description: distorts the ribosome decoding center

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Sensitive Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Sensitive Drug: Hygromycin B
• Molecule Alteration: Missense mutation; Rv2780; c.-32T?>?C
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Yeast strains; 4751
• Experiment for Molecule Alteration: PCR
• Experiment for Drug Resistance: Cell growth rate assay
• Mechanism Description: Loss of UBC7 reduces tolerance to multiple transition metals, which oxidatively damage a range of biological macromolecules, including proteins, and genotoxic agents.

References

• Ref 1: Endoplasmic reticulum and inner nuclear membrane ubiquitin-conjugating enzymes Ubc6 and Ubc7 confer resistance to hygromycin B in Saccharomyces cerevisiae. MicroPubl Biol. 2024 Jul 29;2024:10.17912/micropub.biology.001276.