Molecule Information

General Information of the Molecule (ID: Mol04218)

Name	Microtubule-associated protein 1 light chain 3B II/I (LC3BII/I) ,Homo sapiens
Synonyms	Microtubule-associated protein 1 light chain 3B II/I (LC3BII/I) Click to Show/Hide
Molecule Type	Protein
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Oxaliplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Disease Class: Pancreatic ductal adenocarcinoma [ICD-11: 2C10.0]				[1]
Resistant Disease	Pancreatic ductal adenocarcinoma [ICD-11: 2C10.0]			Disease Info
Resistant Drug	Oxaliplatin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	MiaPaCa-2 cells	Blood	Homo sapiens (Human)	CVCL_0428
Experiment for Molecule Alteration	Western blot assay; qRT-PCR
Experiment for Drug Resistance	Cell viability assay; Annexin V/PI flow cytometry assay
Mechanism Description	A common characteristic among pancreatic cancer patients is the biomechanically altered tumor microenvironment (TME), which among others is responsible for the elevated mechanical stresses in the tumor interior. Although significant research has elucidated the effect of mechanical stress on cancer cell proliferation and migration, it has not yet been investigated how it could affect cancer cell drug sensitivity. Here, we demonstrated that mechanical stress triggers autophagy activation, correlated with increased resistance to oxaliplatin treatment in pancreatic cancer cells.

References

Ref 1	Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition. Commun Biol. 2024 Nov 27;7(1):1581.