Molecule Information

General Information of the Molecule (ID: Mol04214)

Name	Phosphorylated extracellular signal-regulated kinases 1/2 (p-ERK1/2) ,Homo sapiens
Synonyms	Phosphorylated extracellular signal-regulated kinases 1/2 (p-ERK1/2) Click to Show/Hide
Molecule Type	Protein
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Investigative Drug(s)

1 drug(s) in total

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Astragaloside IV

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Lung adenocarcinoma [ICD-11: 2C25.0]				[1]
Resistant Disease	Lung adenocarcinoma [ICD-11: 2C25.0]			Disease Info
Resistant Drug	Astragaloside IV			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	EREG/ErbB/ERK signalling pathway		Regulation	N.A.
In Vitro Model	A549/TR cells	Epithelium	Homo sapiens (Human)	CVCL_C5S0
Experiment for Molecule Alteration	Western blot assay
Experiment for Drug Resistance	Sphere-forming assay; CCK8 assay
Mechanism Description	ASIV reversed taxol resistance through suppression of the stemness-associated genes of spheres in NSCLC. The mechanism exploration revealed that ASIV promoted the K48-linked polyubiquitination of EREG along with degradation. Moreover, EREG could be triggered by chemo-drug treatment. Consequently, EREG bound to the ErbB receptor and activated the ERK signal to regulate the expression of the stemness-associated genes. Inhibition of EREG/ErbB/ERK could reverse the taxol-resistance by inhibiting the stemness-associated genes.

References

Ref 1	Inhibition of EREG/ErbB/ERK by Astragaloside IV reversed taxol-resistance of non-small cell lung cancer through attenuation of stemness via TGFbeta and Hedgehog signal pathway. Cell Oncol (Dordr). 2024 Dec;47(6):2201-2215.