Molecule Information

General Information of the Molecule (ID: Mol04204)

• Name: Proto-oncogene serine/threonine-protein kinase Pim (PIM kinase) ,Homo sapiens
• Synonyms: Proto-oncogene serine/threonine-protein kinase Pim (PIM kinase)
• Molecule Type: Protein

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Preclinical Drug(s) 1 drug(s) in total

AZD3463/Doxorubicin

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Neuroblastoma [ICD-11: 2AOO.11] [1]

• Sensitive Disease: Neuroblastoma [ICD-11: 2AOO.11]
• Sensitive Drug: AZD3463/Doxorubicin
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Sk-N-AS cells; Adrenal; Homo sapiens (Human); CVCL_1700
• In Vitro Model: SK-N-BE cells; N.A.; Homo sapiens (Human); N.A.
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: In the current study, we explore how PIM kinase correlates with the MRP1 drug efflux pump. We demonstrate that PIM kinase inhibition modulates the function of MRP1 mediated efflux of doxorubicin in neuroblastoma.?

References

• Ref 1: PIM Kinase Inhibition Sensitizes Neuroblastoma to Doxorubicin. J Pediatr Surg. 2024 Jul;59(7):1334-1341.