Molecule Information

General Information of the Molecule (ID: Mol04203)
Name
Kelch-like protein 13 (K13/PFK13) ,Plasmodium falciparum
Synonyms
Kelch-like protein 13 (K13/PFK13)
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Molecule Type
Protein
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Kingdom: N.A.
Phylum: Apicomplexa
Class: Aconoidasida
Order: Haemosporida
Family: Plasmodiidae
Genus: Plasmodium
Species: Plasmodium falciparum
Type(s) of Resistant Mechanism of This Molecule
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Artemisinin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Malaria [ICD-11: 1F45.0] [1]
Resistant Disease Malaria [ICD-11: 1F45.0]
 Disease Info 
Resistant Drug Artemisinin
 Drug Info 
Molecule Alteration Mutation
Up-regulation
Experiment for
Molecule Alteration		 RT-PCR
Mechanism Description The most prevalent mutation was?pfk13?Arg622Ile
References
Ref 1 The spread of molecular markers of artemisinin partial resistance and diagnostic evasion in Eritrea: a retrospective molecular epidemiology study. Lancet Microbe. 2025 Feb;6(2):100930.

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