Molecule Information

General Information of the Molecule (ID: Mol04123)
Name
Ladybird homeobox 1 (LBX1) ,Homo sapiens
Synonyms
Ladybird homeobox protein homolog 1
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Molecule Type
Protein
Gene Name
LBX1
Gene ID
10660
Location
chr10:101226994-101229463[-]
Sequence
MTSKEDGKAAPGEERRRSPLDHLPPPANSNKPLTPFSIEDILNKPSVRRSYSLCGAAHLL
AAADKHAQGGLPLAGRALLSQTSPLCALEELASKTFKGLEVSVLQAAEGRDGMTIFGQRQ
TPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKL
KRDLEEMKADVESAKKLGPSGQMDIVALAELEQNSEATAGGGGGCGRAKSRPGSPVLPPG
APKAPGAGALQLSPASPLTDQPASSQDCSEDEEDEEIDVDD
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Function
Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. .
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Uniprot ID
LBX1_HUMAN
Ensembl ID
ENSG00000138136
HGNC ID
HGNC:16960
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  MRAP: Metabolic Reprogramming via Altered Pathways
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Enzalutamide
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Metabolic Reprogramming via Altered Pathways (MRAP) Click to Show/Hide
Disease Class: Prostate cancer [ICD-11: 2C82.0] [1]
Metabolic Type Glutamine metabolism
Resistant Disease Prostate cancer [ICD-11: 2C82.0]
 Disease Info 
Resistant Drug Enzalutamide
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model LNCaP cells Prostate Homo sapiens (Human) CVCL_0395
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 Cell viability assay
Mechanism Description We compared the transcriptomic profile of paired enzalutamide-sensitive and resistant LNCaP and C4-10B prostate cancer cells for identification of genes involved in drug resistance by performing an unbiased bioinformatics analysis and further validation
Disease Class: Prostate cancer [ICD-11: 2C82.0] [1]
Metabolic Type Glutamine metabolism
Resistant Disease Prostate cancer [ICD-11: 2C82.0]
 Disease Info 
Resistant Drug Enzalutamide
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model C4-2B cells Prostate Homo sapiens (Human) CVCL_4784
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 Cell viability assay
Mechanism Description We compared the transcriptomic profile of paired enzalutamide-sensitive and resistant LNCaP and C4-19B prostate cancer cells for identification of genes involved in drug resistance by performing an unbiased bioinformatics analysis and further validation
References
Ref 1 Metabolic Reprogramming and Predominance of Solute Carrier Genes during Acquired Enzalutamide Resistance in Prostate Cancer. Cells. 2020 Nov 24;9(12):2535.

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