Molecule Information

General Information of the Molecule (ID: Mol04099)
Name
CKLF-like MARVEL transmembrane domain-containing 3 (CMTM3) ,Homo sapiens
Synonyms
Chemokine-like factor superfamily member 3
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Molecule Type
Protein
Gene Name
CMTM3
Gene ID
123920
Location
chr16:66603874-66613892[+]
Sequence
MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV
ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA
IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD
SD
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Uniprot ID
CKLF3_HUMAN
Ensembl ID
ENSG00000140931
HGNC ID
HGNC:19174
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  MRAP: Metabolic Reprogramming via Altered Pathways
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Enzalutamide
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Metabolic Reprogramming via Altered Pathways (MRAP) Click to Show/Hide
Disease Class: Prostate cancer [ICD-11: 2C82.0] [1]
Metabolic Type Glutamine metabolism
Resistant Disease Prostate cancer [ICD-11: 2C82.0]
 Disease Info 
Resistant Drug Enzalutamide
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model C4-2B cells Prostate Homo sapiens (Human) CVCL_4784
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 Cell viability assay
Mechanism Description We compared the transcriptomic profile of paired enzalutamide-sensitive and resistant LNCaP and C4-17B prostate cancer cells for identification of genes involved in drug resistance by performing an unbiased bioinformatics analysis and further validation
Disease Class: Prostate cancer [ICD-11: 2C82.0] [1]
Metabolic Type Glutamine metabolism
Resistant Disease Prostate cancer [ICD-11: 2C82.0]
 Disease Info 
Resistant Drug Enzalutamide
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model LNCaP cells Prostate Homo sapiens (Human) CVCL_0395
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 Cell viability assay
Mechanism Description We compared the transcriptomic profile of paired enzalutamide-sensitive and resistant LNCaP and C4-8B prostate cancer cells for identification of genes involved in drug resistance by performing an unbiased bioinformatics analysis and further validation
References
Ref 1 Metabolic Reprogramming and Predominance of Solute Carrier Genes during Acquired Enzalutamide Resistance in Prostate Cancer. Cells. 2020 Nov 24;9(12):2535.

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