Molecule Information

General Information of the Molecule (ID: Mol04049)

Name	Mitochondrial pyruvate carrier (MPC) ,Homo sapiens
Synonyms	Brain protein 44 Click to Show/Hide
Molecule Type	Protein
Gene Name	MPC2
Gene ID	25874
Location	chr1:167916675-167937072[-]
Sequence	MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADM ARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQE LKAKAHK Click to Show/Hide
Function	Mediates the uptake of pyruvate into mitochondria. . Click to Show/Hide
Uniprot ID	MPC2_HUMAN
Ensembl ID	ENSG00000143158
HGNC ID	HGNC:24515
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

MRAP: Metabolic Reprogramming via Altered Pathways

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Enzalutamide

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Metabolic Reprogramming via Altered Pathways (MRAP)		Click to Show/Hide
Disease Class: Prostate cancer [ICD-11: 2C82.0]			[1]
Metabolic Type	Glucose metabolism
Resistant Disease	Prostate cancer [ICD-11: 2C82.0]		Disease Info
Resistant Drug	Enzalutamide		Drug Info
Molecule Alteration	Expression	Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vivo Model	Nude (nu/nu) mice, with LNCaP cells		Mice
Experiment for Molecule Alteration	qRT-PCR; Western blot analysis
Experiment for Drug Resistance	Tumor volume assay
Mechanism Description	In this study, we demonstrate, for the first time, that MPC was significantly expressed at low levels in NEPC cells and that its downregulation contributed to NED and enzalutamide resistance. Moreover, MPC overexpression increased enzalutamide sensitivity and reversed NED in adenocarcinoma prostate cancer. These effects were likely mediated through the EMT induced by nuclear PKM2 translocation, which is controlled by acetyl-CoA, a product of pyruvate catabolism.

References

Ref 1	Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC). Mol Metab. 2022 May;59:101466.