Molecule Information

General Information of the Molecule (ID: Mol04009)
Name
6-Phosphogluconate dehydrogenase (6PGD) ,Homo sapiens
Molecule Type
Protein
Gene Name
PGD
Gene ID
5226
Location
chr1:10398592-10420511[+]
Sequence
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKE
MVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG
ILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAG
HFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL
KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQA
SKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIAL
MWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPM
PCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSS
YNA
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3D-structure
PDB ID
2JKV
Classification
Oxidoreductase
Method
X-ray diffraction
Resolution
2.53  Å
Function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. .
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Uniprot ID
6PGD_HUMAN
Ensembl ID
ENSG00000142657
HGNC ID
HGNC:8891
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  MRAP: Metabolic Reprogramming via Altered Pathways
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Epirubicin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Metabolic Reprogramming via Altered Pathways (MRAP) Click to Show/Hide
Disease Class: Breast adenocarcinoma [ICD-11: 2C60.1] [1]
Metabolic Type Glucose metabolism
Resistant Disease Breast adenocarcinoma [ICD-11: 2C60.1]
 Disease Info 
Resistant Drug Epirubicin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Adrenergic signaling in cardiomyocytes Activation hsa04261
In Vitro Model BT-549 cells Breast Homo sapiens (Human) CVCL_1092
MDA-MB-23 cells1 Breast Homo sapiens (Human) CVCL_0062
Experiment for
Molecule Alteration		 qRT-PCR; Western blot analysis
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description In summary, this study investigated the important role of 6PGD in promoting TNBC progression and attenuating chemotherapy response efficacy of chemotherapy-resistant cells. Inhibition of 6PGD and epirubicin exerted synergistic effects on resistant cells, effectively increasing the sensitivity of resistant cells to chemotherapeutic agents through metabolic remodeling. Therefore, 6PGD might be a potential and important metabolic target in clinical applications such as reversing chemotherapy resistance in TNBC and tumor therapies.
References
Ref 1 Inhibition of 6-Phosphogluconate Dehydrogenase Reverses Epirubicin Resistance Through Metabolic Reprograming in Triple-Negative Breast Cancer Cells. Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231190737.

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