Molecule Information

General Information of the Molecule (ID: Mol02230)

• Name: Long non-protein coding RNA (NONRATT007560.2) ,Rattus norvegicus
• Synonyms: NONRATT007560.2
• Molecule Type: LncRNA
• Gene Name: NONRATT007560.2

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

D-Glucose

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Diabetic cardiomyopathy [1]

• Resistant Disease: Diabetic cardiomyopathy [ICD-11: BC43.7]
• Resistant Drug: D-Glucose
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Rat primary cardiomyocytes; Embryonic heart; Rattus norvegicus (Rat); CVCL_0286
• Experiment for Molecule Alteration: RNA-seq assay
• Experiment for Drug Resistance: Cellular ROS detection assay; Flow cytometry assay
• Mechanism Description: RNA-Seq analysis and functional characterization revealed LncRNA NONRATT007560.2 regulated cardiomyocytes oxidative stress and apoptosis induced by high glucose.

References

• Ref 1: RNA-Seq analysis and functional characterization revealed lncRNA NONRATT007560.2 regulated cardiomyocytes oxidative stress and apoptosis induced by high glucoseJ Cell Biochem. 2019 Oct;120(10):18278-18287. doi: 10.1002/jcb.29134. Epub 2019 May 29.