Molecule Information

General Information of the Molecule (ID: Mol02218)

• Name: Long non-protein coding RNA (AK003290) ,Homo sapiens
• Synonyms: AK003290
• Molecule Type: LncRNA
• Gene Name: AK003290

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Tanshinone IIA

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Acute myocardial infarction [1]

• Resistant Disease: Acute myocardial infarction [ICD-11: BA41.1]
• Resistant Drug: Tanshinone IIA
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: H9C2 cells; Ovary; Cricetulus griseus (Chinese hamster); CVCL_A0TS
• In Vivo Model: I/R female C57BL/6 mice model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay; qRT-PCR; Western bloting analysis; RNA pull down assay; FISH assay; Luciferase assay
• Experiment for Drug Resistance: Flow cytometry assay; LDH and MDA detection assay; ROS detection assay; Dual-Luciferase assay
• Mechanism Description: TSA exerts the protective role against H/R induced apoptosis, oxidative and MMP loss of cardiomyocytes via regulating AK003290 and miR-124-5p signaling.

References

• Ref 1: Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocyte injury via lncRNA AK003290/miR-124-5p signalingBMC Mol Cell Biol. 2020 Mar 27;21(1):20. doi: 10.1186/s12860-020-00264-3.