Molecule Information

General Information of the Molecule (ID: Mol02207)

• Name: Long non-protein coding RNA (LNC010561) ,Homo sapiens
• Synonyms: LNC010561
• Molecule Type: LncRNA
• Gene Name: LNC010561

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Melatonin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Breast adenocarcinoma [1]

• Resistant Disease: Breast adenocarcinoma [ICD-11: 2C60.1]
• Resistant Drug: Melatonin
• Molecule Alteration: Down-regulation; Interaction
• Experimental Note: Revealed Based on the Cell Line Data
• In Vivo Model: BALB/c nude mice model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay; Microarray assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Knockdown of FKBP3 and lnc010561 inhibited breast cancer proliferation and invasion, and induced apoptosis.

References

• Ref 1: Melatonin Regulates Breast Cancer Progression by the lnc010561/miR-30/FKBP3 AxisMol Ther Nucleic Acids. 2020 Mar 6;19:765-774. doi: 10.1016/j.omtn.2019.12.019. Epub 2019 Dec 24.