Molecule Information

General Information of the Molecule (ID: Mol02204)

• Name: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) ,Rattus norvegicus
• Synonyms: MALAT1
• Molecule Type: LncRNA
• Gene Name: MALAT1

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Insulin recombinant

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Type 2 diabetes mellitus [ICD-11: 5A11.0] [2]

• Resistant Disease: Type 2 diabetes mellitus [ICD-11: 5A11.0]
• Resistant Drug: Insulin recombinant
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: Male C57BL/6J mouse model; Mus musculus
• Experiment for Molecule Alteration: RAP-PCR; qRT-PCR
• Mechanism Description: The overall metabolic impact of the absence of Malat1 on adipose tissue accretion and glucose intolerance is either physiologically not relevant upon aging and obesity, or that it is masked by as yet unknown compensatory mechanisms.

References

• Ref 1: Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer. Carcinogenesis. 2023 Aug 18;44(6):497-510.
• Ref 2: Loss of Malat1 does not modify age- or diet-induced adipose tissue accretion and insulin resistance in micePLoS One. 2018 May 10;13(5):e0196603. doi: 10.1371/journal.pone.0196603. eCollection 2018.