Molecule Information

General Information of the Molecule (ID: Mol02203)

• Name: Nuclear paraspeckle assembly transcript 1 (NEAT1) ,Danio rerio
• Synonyms: NEAT1
• Molecule Type: LncRNA
• Gene Name: NEAT1

Kingdom: Metazoa
Phylum: Chordata
Class: Actinopteri
Order: Cypriniformes
Family: Danionidae
Genus: Danio
Species: Danio rerio

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Isoliquiritigenin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Brain glioma [1]

• Resistant Disease: Brain glioma [ICD-11: 2A00.0]
• Resistant Drug: Isoliquiritigenin
• Molecule Alteration: Down-regulation; Interaction
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: C6 cells; Brain; Rattus norvegicus (Rat); CVCL_0194
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Immunofluorescence assay; ELISA assay; Luciferase assay; Overexpression assay
• Mechanism Description: LncRNA NEAT1 overexpression reversed ISL-mediated increase in miR-194-5p expression, and thereby attenuated FGF-2, TGF-beta and VEGF production.

References

• Ref 1: Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1J Exp Clin Cancer Res. 2019 Aug 22;38(1):371. doi: 10.1186/s13046-019-1361-2.