Molecule Information

General Information of the Molecule (ID: Mol02201)

• Name: Urothelial cancer associated 1 (UCA1) ,Rattus norvegicus
• Synonyms: UCA1
• Molecule Type: LncRNA
• Gene Name: UCA1

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Epirubicin

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Bladder cancer [ICD-11: 2C94.0] [1]

• Sensitive Disease: Bladder cancer [ICD-11: 2C94.0]
• Sensitive Drug: Epirubicin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: lncRNA UCA1/miR-30a-3p/PPARalpha signaling pathway; Regulation; N.A.
• In Vitro Model: 5637 cells; Bladder; Homo sapiens (Human); CVCL_0126
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: In this study, we demonstrated that lncRNA UCA1 inhibits epirubicin-induced cell apoptosis by supporting abnormal lipid metabolism in bladder cancer cells. Mechanistically, lncRNA UCA1 promotes lipid accumulation in vitro and in vivo by upregulating PPAR mRNA and protein expression, which is mediated by miR-30a-3p. Knockdown of lncRNA UCA1 increased epirubicin-induced apoptosis via miR-30a-3p/PPAR and downstream p-AKT/p-GSK-3beta/beta-catenin signaling.

Investigative Drug(s) 1 drug(s) in total

Kainic acid

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Temporal lobe epilepsy [ICD-11: 8A61.3Y] [2]

• Resistant Disease: Temporal lobe epilepsy [ICD-11: 8A61.3Y]
• Resistant Drug: Kainic acid
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Epileptic rats model; Rattus norvegicus
• Experiment for Molecule Alteration: qRT-PCR; Immunofluorescence assay; Western bloting analysis; Overexpression assay
• Experiment for Drug Resistance: Morris water maze analysis
• Mechanism Description: LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathway.

References

• Ref 1: Long noncoding RNA UCA1 inhibits epirubicin-induced apoptosis by activating PPARalpha-mediated lipid metabolism. Exp Cell Res. 2024 Oct 1;442(2):114271.
• Ref 2: LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathwayJ Cell Biochem. 2020 Oct;121(10):4261-4270. doi: 10.1002/jcb.29634. Epub 2020 Jan 7.