Molecule Information

General Information of the Molecule (ID: Mol02201)

• Name: Urothelial cancer associated 1 (UCA1) ,Rattus norvegicus
• Synonyms: UCA1
• Molecule Type: LncRNA
• Gene Name: UCA1

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Kainic acid

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Temporal lobe epilepsy [1]

• Resistant Disease: Temporal lobe epilepsy [ICD-11: 8A61.3Y]
• Resistant Drug: Kainic acid
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Epileptic rats model; Rattus norvegicus
• Experiment for Molecule Alteration: qRT-PCR; Immunofluorescence assay; Western bloting analysis; Overexpression assay
• Experiment for Drug Resistance: Morris water maze analysis
• Mechanism Description: LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathway.

References

• Ref 1: LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathwayJ Cell Biochem. 2020 Oct;121(10):4261-4270. doi: 10.1002/jcb.29634. Epub 2020 Jan 7.