Molecule Information

General Information of the Molecule (ID: Mol02200)

• Name: Ewing sarcoma associated transcript 1 (EWSAT1) ,Rattus norvegicus
• Synonyms: EWSAT1
• Molecule Type: LncRNA
• Gene Name: EWSAT1

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Formononetin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Solid tumour/cancer [1]

• Resistant Disease: Solid tumour/cancer [ICD-11: 2A00-2F9Z]
• Resistant Drug: Formononetin
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: human umbilical vein endothelial cells; N.A.; Homo sapiens (Human); N.A.
• In Vivo Model: Female SD rats model; Rattus norvegicus
• Experiment for Molecule Alteration: Microarray assay; qRT-PCR; Western bloting analysis
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: Formononetin, J1 and J2 have different effects on endothelial cells via EWSAT1-TRAF6 and its downstream pathway.

References

• Ref 1: Formononetin, J1 and J2 have different effects on endothelial cells via EWSAT1-TRAF6 and its downstream pathwayJ Cell Mol Med. 2020 Jan;24(1):875-885. doi: 10.1111/jcmm.14797. Epub 2019 Nov 19.