Molecule Information

General Information of the Molecule (ID: Mol02198)

Name	SIRT1 antisense RNA (SIRT1-AS) ,Homo sapiens
Synonyms	SIRT1-AS Click to Show/Hide
Molecule Type	LncRNA
Gene Name	SIRT1-AS
Gene ID	106633813
HGNC ID	HGNC:51912
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s)

1 drug(s) in total

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Astragaloside IV

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Pulmonary fibrosis [ICD-11: CB03.1]				[1]
Resistant Disease	Pulmonary fibrosis [ICD-11: CB03.1]			Disease Info
Resistant Drug	Astragaloside IV			Drug Info
Molecule Alteration	Down-regulation		Expression
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	RLE-6TN cells	Lung	Rattus norvegicus (Rat)	CVCL_4693
Experiment for Molecule Alteration	Overexpression assay; Knockdown assay
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Collectively, sirt1 AS was critical for ASV-mediated inhibition of IPF progression and targeting of sirt1 AS by ASV could be a potential therapeutic approach for IPF.

References

Ref 1	Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transitionAging (Albany NY). 2020 Mar 6;12(5):4322-4336. doi: 10.18632/aging.102882. Epub 2020 Mar 6.

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