Molecule Information

General Information of the Molecule (ID: Mol02197)

• Name: myosin heavy chain associated RNA transcript (MHRT) ,Homo sapiens
• Synonyms: MHRT
• Molecule Type: LncRNA
• Gene Name: MHRT
• Gene ID: 104564225
• HGNC ID: HGNC:51291

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Chronic heart failure [1]

• Resistant Disease: Chronic heart failure [ICD-11: BD10.2]
• Resistant Drug: Hydrogen peroxide
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: AC16 cells; Heart; Homo sapiens (Human); CVCL_4U18
• Experiment for Molecule Alteration: qRT-PCR; Overexpression assay
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: Chronic heart failure patients with lower expression levels of LncRNA MHRT had worse survival conditions compared to patients with higher expression levels of LncRNA MHRT.

References

• Ref 1: Circulating lncRNA MHRT predicts survival of patients with chronic heart failureJ Geriatr Cardiol. 2019 Nov;16(11):818-821. doi: 10.11909/j.issn.1671-5411.2019.11.006.