Molecule Information

General Information of the Molecule (ID: Mol02195)

Name	tumor protein p53 pathway corepressor 1 (TP53COR1) ,Homo sapiens
Synonyms	TP53COR1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	TP53COR1
Gene ID	102800311
HGNC ID	HGNC:43652
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Chloroquinine phosphate

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Colon cancer [ICD-11: 2B90.1]				[1]
Resistant Disease	Colon cancer [ICD-11: 2B90.1]			Disease Info
Resistant Drug	Chloroquinine phosphate			Drug Info
Molecule Alteration	Up-regulation		Interaction
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HT29 Cells	Colon	Homo sapiens (Human)	CVCL_A8EZ
	HCT116 cells	Colon	Homo sapiens (Human)	CVCL_0291
Experiment for Molecule Alteration	qRT-PCR; Western bloting analysis; Immunoprecipitation; Knockdown assay
Mechanism Description	LincRNA-p21 Mediates the Anti-Cancer Effect of Ginkgo Biloba Extract EGb 761 by Stabilizing E-Cadherin Protein in Colon Cancer.

References

Ref 1	lincRNA-p21 Mediates the Anti-Cancer Effect of Ginkgo Biloba Extract EGb 761 by Stabilizing E-Cadherin Protein in Colon CancerMed Sci Monit. 2018 Dec 30;24:9488-9496. doi: 10.12659/MSM.911924.

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