Molecule Information

General Information of the Molecule (ID: Mol02187)

• Name: HOX transcript antisense RNA (HOTAIR) ,Mus musculus
• Synonyms: Hotair
• Molecule Type: LncRNA
• Gene Name: Hotair
• Gene ID: 100503872
• Location: chr15:102,852,494-102,856,165[-]
• Ensembl ID: ENSMUSG00000086903

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 2 drug(s) in total

Andrographolide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Chronic obstructive pulmonary disease [ICD-11: CA22.0] [1]

• Resistant Disease: Chronic obstructive pulmonary disease [ICD-11: CA22.0]
• Resistant Drug: Andrographolide
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SV40 cells; N.A.; N.A.; N.A.
• In Vivo Model: Male BALB/c mice moddel; Mus musculus
• Mechanism Description: Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIR.

Disease Class: Pulmonary dysfunction [ICD-11:BB01.1] [1]

• Resistant Disease: Pulmonary dysfunction [ICD-11:BB01.1]
• Resistant Drug: Andrographolide
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: HBECs; Bronchus; Homo sapiens (Human); CVCL_0287
• In Vivo Model: Male BALB/c mice CS-exposed model; Mus musculus
• Experiment for Drug Resistance: Annexin V-PI Apoptosis detection; Flow cytometry assay
• Mechanism Description: Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIR.

Silicon dioxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Silicosis [ICD-11: CA60.0Z] [1]

• Resistant Disease: Silicosis [ICD-11: CA60.0Z]
• Resistant Drug: Silicon dioxide
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: A549 cells; Lung; Homo sapiens (Human); CVCL_0023
• In Vitro Model: MRC-5 cells; Lung; Homo sapiens (Human); CVCL_0440
• In Vitro Model: NIH/3T3 cells; Whole embryo; Mus musculus (Mouse); CVCL_0594
• In Vitro Model: HBE cells; Bronchus; Homo sapiens (Human); CVCL_0287
• In Vivo Model: Silica-Induced lung Fibrosis mouse model; Lung Fibrosis MiR-326 overexpression mouse model; Mus musculus
• Experiment for Molecule Alteration: Western bloting analysis; Immunofluorescence assay; Knockdown assay
• Experiment for Drug Resistance: Dual luciferase reporter assays
• Mechanism Description: miR-326 Inhibits Inflammation and Promotes Autophagy in Silica-Induced Pulmonary Fibrosis through Targeting TNFSF14 and PTBP1.

References

• Ref 1: Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIRToxicology. 2019 Jun 15;422:84-94. doi: 10.1016/j.tox.2019.05.009. Epub 2019 May 23.